Suppression of hyperglycemia and hepatic steatosis by black-soybean-leaf extract via enhanced adiponectin-receptor signaling and AMPK activation = 검정콩잎 추출물의 아디포넥틴 리셉터 신호전달과 AMPK 활성 증가를 통한 고혈당 및 지방간 개선 효능

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Title
Suppression of hyperglycemia and hepatic steatosis by black-soybean-leaf extract via enhanced adiponectin-receptor signaling and AMPK activation = 검정콩잎 추출물의 아디포넥틴 리셉터 신호전달과 AMPK 활성 증가를 통한 고혈당 및 지방간 개선 효능
Author(s)
Hua Li; Un-Hee Kim; Jeong Hyun Yoon; Hyeon Seon Ji; Hye-Mi Park; Ho Yong ParkTae Sook Jeong
Bibliographic Citation
Journal of Agricultural and Food Chemistry, vol. 67, no. 1, pp. 90-101
Publication Year
2019
Abstract
Yellow-soybean-leaf extract includes kaempferol glycosides and pheophorbides that reduce obesity and plasma glucose levels. This study researched the molecular mechanisms underlying the glucose-lowering effect of the extract of black-soybean leaves (EBL), which mainly contains quercetin glycosides and isorhamnetin glycosides, in mice with high-fat-diet (HFD)-induced obesity and diabetes and in HepG2 cells. Twelve weeks of EBL supplementation decreased body weight and fasting glucose, glycated hemoglobin, insulin, triglyceride, and nonesterified fatty acid levels. Histological analyses manifested that EBL suppressed hepatic steatosis. Interestingly, EBL significantly improved plasma adiponectin levels and increased adiponectin-receptor-gene (AdipoR1 and AdipoR2) expression in the liver. EBL restored the effects of HFD on hepatic AMP-activated protein kinase (AMPK) and on the family of peroxisome proliferator-activated receptors (PPARα, PPARδ, and PPARγ), which are associated with fatty acid metabolism and are downstream of the adiponectin receptors. Hence, EBL effectively diminished hyperglycemia and hepatic steatosis through enhancing adiponectin-induced signaling and AMPK activation in the liver.
Keyword
adiponectinAMPKblack-soybean leafhyperglycemiasteatosis
ISSN
0021-8561
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jafc.8b04527
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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