An antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model

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dc.contributor.authorJaemin Lee-
dc.contributor.authorT H Kang-
dc.contributor.authorWonbeak Yoo-
dc.contributor.authorHyunji Choi-
dc.contributor.authorSungyea Jo-
dc.contributor.authorKyungsu Kong-
dc.contributor.authorSang-Rae Lee-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorJi-Su Kim-
dc.contributor.authorD Cho-
dc.contributor.authorJanghwan Kim-
dc.contributor.authorJ Y Kim-
dc.contributor.authorEun Soo Kwon-
dc.contributor.authorSeokho Kim-
dc.date.accessioned2019-04-09T16:30:10Z-
dc.date.available2019-04-09T16:30:10Z-
dc.date.issued2019-
dc.identifier.issn2326-6066-
dc.identifier.uri10.1158/2326-6066.CIR-18-0317ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18420-
dc.description.abstractNatural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer immunotherapy is to increase trafficking of NK cells to tumor tissues. Here, we developed an antibody-based NK-cell-homing protein, named NK-cell-recruiting protein-conjugated antibody (NRP-body). The effect of NRP-body on infiltration of NK cells into primary and metastatic pancreatic cancer was evaluated in vitro and in murine pancreatic ductal adenocarcinoma models. The NRP-body increased NK-cell infiltration of tumors along a CXCL16 gradient (CXCL16 is cleaved from the NRP-body by furin expressed on the surface of pancreatic cancer cells). CXCL16 induced NK-cell infiltration by activating RhoA via the ERK signaling cascade. Administration of the NRP-body to pancreatic cancer model mice increased tumor tissue infiltration of transferred NK cells and reduced the tumor burden compared with that in controls. Overall survival of NRP-body-treated mice (even the metastasis models) was higher than that of mice receiving NK cells alone. In conclusion, increasing NK-cell infiltration into tumor tissues improved response to this cancer immunotherapy. The combination of an NRP-body with NK-cell therapy might be useful for treating pancreatic cancer.-
dc.publisherAmer Assoc Cancer Research-
dc.titleAn antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model-
dc.title.alternativeAn antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model-
dc.typeArticle-
dc.citation.titleCancer Immunology Research-
dc.citation.number2-
dc.citation.endPage229-
dc.citation.startPage219-
dc.citation.volume7-
dc.contributor.affiliatedAuthorJaemin Lee-
dc.contributor.affiliatedAuthorWonbeak Yoo-
dc.contributor.affiliatedAuthorHyunji Choi-
dc.contributor.affiliatedAuthorSungyea Jo-
dc.contributor.affiliatedAuthorKyungsu Kong-
dc.contributor.affiliatedAuthorSang-Rae Lee-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorJi-Su Kim-
dc.contributor.affiliatedAuthorJanghwan Kim-
dc.contributor.affiliatedAuthorEun Soo Kwon-
dc.contributor.affiliatedAuthorSeokho Kim-
dc.contributor.alternativeName이재민-
dc.contributor.alternativeName강태흥-
dc.contributor.alternativeName유원백-
dc.contributor.alternativeName최현지-
dc.contributor.alternativeName조성예-
dc.contributor.alternativeName공경수-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName조덕-
dc.contributor.alternativeName김장환-
dc.contributor.alternativeName김정윤-
dc.contributor.alternativeName권은수-
dc.contributor.alternativeName김석호-
dc.identifier.bibliographicCitationCancer Immunology Research, vol. 7, no. 2, pp. 219-229-
dc.identifier.doi10.1158/2326-6066.CIR-18-0317-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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