DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jaemin Lee | - |
dc.contributor.author | T H Kang | - |
dc.contributor.author | Wonbeak Yoo | - |
dc.contributor.author | Hyunji Choi | - |
dc.contributor.author | Sungyea Jo | - |
dc.contributor.author | Kyungsu Kong | - |
dc.contributor.author | Sang-Rae Lee | - |
dc.contributor.author | Sun-Uk Kim | - |
dc.contributor.author | Ji-Su Kim | - |
dc.contributor.author | D Cho | - |
dc.contributor.author | Janghwan Kim | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | Eun Soo Kwon | - |
dc.contributor.author | Seokho Kim | - |
dc.date.accessioned | 2019-04-09T16:30:10Z | - |
dc.date.available | 2019-04-09T16:30:10Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2326-6066 | - |
dc.identifier.uri | 10.1158/2326-6066.CIR-18-0317 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18420 | - |
dc.description.abstract | Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer immunotherapy is to increase trafficking of NK cells to tumor tissues. Here, we developed an antibody-based NK-cell-homing protein, named NK-cell-recruiting protein-conjugated antibody (NRP-body). The effect of NRP-body on infiltration of NK cells into primary and metastatic pancreatic cancer was evaluated in vitro and in murine pancreatic ductal adenocarcinoma models. The NRP-body increased NK-cell infiltration of tumors along a CXCL16 gradient (CXCL16 is cleaved from the NRP-body by furin expressed on the surface of pancreatic cancer cells). CXCL16 induced NK-cell infiltration by activating RhoA via the ERK signaling cascade. Administration of the NRP-body to pancreatic cancer model mice increased tumor tissue infiltration of transferred NK cells and reduced the tumor burden compared with that in controls. Overall survival of NRP-body-treated mice (even the metastasis models) was higher than that of mice receiving NK cells alone. In conclusion, increasing NK-cell infiltration into tumor tissues improved response to this cancer immunotherapy. The combination of an NRP-body with NK-cell therapy might be useful for treating pancreatic cancer. | - |
dc.publisher | Amer Assoc Cancer Research | - |
dc.title | An antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model | - |
dc.title.alternative | An antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model | - |
dc.type | Article | - |
dc.citation.title | Cancer Immunology Research | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 229 | - |
dc.citation.startPage | 219 | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Jaemin Lee | - |
dc.contributor.affiliatedAuthor | Wonbeak Yoo | - |
dc.contributor.affiliatedAuthor | Hyunji Choi | - |
dc.contributor.affiliatedAuthor | Sungyea Jo | - |
dc.contributor.affiliatedAuthor | Kyungsu Kong | - |
dc.contributor.affiliatedAuthor | Sang-Rae Lee | - |
dc.contributor.affiliatedAuthor | Sun-Uk Kim | - |
dc.contributor.affiliatedAuthor | Ji-Su Kim | - |
dc.contributor.affiliatedAuthor | Janghwan Kim | - |
dc.contributor.affiliatedAuthor | Eun Soo Kwon | - |
dc.contributor.affiliatedAuthor | Seokho Kim | - |
dc.contributor.alternativeName | 이재민 | - |
dc.contributor.alternativeName | 강태흥 | - |
dc.contributor.alternativeName | 유원백 | - |
dc.contributor.alternativeName | 최현지 | - |
dc.contributor.alternativeName | 조성예 | - |
dc.contributor.alternativeName | 공경수 | - |
dc.contributor.alternativeName | 이상래 | - |
dc.contributor.alternativeName | 김선욱 | - |
dc.contributor.alternativeName | 김지수 | - |
dc.contributor.alternativeName | 조덕 | - |
dc.contributor.alternativeName | 김장환 | - |
dc.contributor.alternativeName | 김정윤 | - |
dc.contributor.alternativeName | 권은수 | - |
dc.contributor.alternativeName | 김석호 | - |
dc.identifier.bibliographicCitation | Cancer Immunology Research, vol. 7, no. 2, pp. 219-229 | - |
dc.identifier.doi | 10.1158/2326-6066.CIR-18-0317 | - |
dc.description.journalClass | Y | - |
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