DC Field | Value | Language |
---|---|---|
dc.contributor.author | P Gunasekaran | - |
dc.contributor.author | G Rajasekaran | - |
dc.contributor.author | E H Han | - |
dc.contributor.author | Y H Chung | - |
dc.contributor.author | Y J Choi | - |
dc.contributor.author | Y J Yang | - |
dc.contributor.author | J E Lee | - |
dc.contributor.author | H N Kim | - |
dc.contributor.author | Kiram Lee | - |
dc.contributor.author | Jin Seok Kim | - |
dc.contributor.author | Hyun-Jun Lee | - |
dc.contributor.author | E J Choi | - |
dc.contributor.author | E K Kim | - |
dc.contributor.author | S Y Shin | - |
dc.contributor.author | J K Bang | - |
dc.date.accessioned | 2019-04-09T16:30:10Z | - |
dc.date.available | 2019-04-09T16:30:10Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | 10.1038/s41598-018-37785-z | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18421 | - |
dc.description.abstract | The emergence of multi-drug resistant bacteria forces the therapeutic world into a position, where the development of new and alternative kind of antibiotics is highly important. Herein, we report the development of triazine-based amphiphilic small molecular antibacterial agents as mimics of lysine- and arginine-based cationic peptide antibiotics (CPAs). These compounds were screened against a panel of both Gram-positive and Gram-negative bacterial strains. Further, anti-inflammatory evaluation of these compounds led to the identification of four efficient compounds, DG-5, DG-6, DL-5, and DL-6. These compounds displayed significant potency against drug-resistant bacteria, including methicillin-resistant S. aureus (MRSA), multidrug-resistant P. aeruginosa (MDRPA), and vancomycin-resistant E. faecium (VREF). Mechanistic studies, including cytoplasmic membrane depolarization, confocal imaging and flow cytometry suggest that DG-5, DG-6, and DL-5 kill bacteria by targeting bacterial membrane, while DL-6 follows intracellular targeting mechanism. We also demonstrate that these molecules have therapeutic potential by showing the efficiency of DG-5 in preventing the lung inflammation of lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. More interestingly, DL-6 exhibited impressive potency on atopic dermatitis (AD)-like skin lesions in BALB/c mice model by suppressing pro-inflammatory cytokines. Collectively, these results suggest that they can serve a new class of antimicrobial, anti-inflammatory and anti-atopic agents with promising therapeutic potential. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Cationic amphipathic triazines with potent anti-bacterial, anti-inflammatory and anti-atopic dermatitis properties | - |
dc.title.alternative | Cationic amphipathic triazines with potent anti-bacterial, anti-inflammatory and anti-atopic dermatitis properties | - |
dc.type | Article | - |
dc.citation.title | Scientific Reports | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 1292 | - |
dc.citation.startPage | 1292 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kiram Lee | - |
dc.contributor.affiliatedAuthor | Jin Seok Kim | - |
dc.contributor.affiliatedAuthor | Hyun-Jun Lee | - |
dc.contributor.alternativeName | Gunasekaran | - |
dc.contributor.alternativeName | Rajasekaran | - |
dc.contributor.alternativeName | 한은희 | - |
dc.contributor.alternativeName | 정영호 | - |
dc.contributor.alternativeName | 최영진 | - |
dc.contributor.alternativeName | 양유진 | - |
dc.contributor.alternativeName | 이지은 | - |
dc.contributor.alternativeName | 김학남 | - |
dc.contributor.alternativeName | 이기람 | - |
dc.contributor.alternativeName | 김진석 | - |
dc.contributor.alternativeName | 이현준 | - |
dc.contributor.alternativeName | 최은주 | - |
dc.contributor.alternativeName | 김은경 | - |
dc.contributor.alternativeName | 신송엽 | - |
dc.contributor.alternativeName | 방정규 | - |
dc.identifier.bibliographicCitation | Scientific Reports, vol. 9, pp. 1292-1292 | - |
dc.identifier.doi | 10.1038/s41598-018-37785-z | - |
dc.description.journalClass | Y | - |
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.