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- Title
- Effect of cinnamamides on atopic dermatitits through regulation of IL-4 in CD4+ cells
- Author(s)
- E J Choi; Young Bae Ryu; Y Tang; Bo Ram Kim; Woo Song Lee; T Debnath; M Fan; E K Kim; H S Lee
- Bibliographic Citation
- Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, no. 1, pp. 613-619
- Publication Year
- 2019
- Abstract
- This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum immunoglobulin (Ig) levels and expression of T-helper (Th)1/Th2 cytokines. Moreover, cinnamamides suppressed interleukin (IL)-4, which plays a crucial role in preparing naive clusters of differentiation (CD)4+ T cells, and decreased the cervical lymph node size and weight. Interestingly, in almost all cases, NCPA exhibited higher anti-AD activity compared to NCT. These results strongly indicate that NCPA may have potential as an anti-AD agent, and further mechanistic comparative studies of NCT and NCPA are required to determine the cause of differences in biological activity.
- Keyword
- Atopic dermatitisCD4+ T cellsIL-4Th1/Th2 cytokinescinnamamides
- ISSN
- 1475-6366
- Publisher
- T&F (Taylor & Francis)
- DOI
- http://dx.doi.org/10.1080/14756366.2019.1569647
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
- Files in This Item:
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