Effect of cinnamamides on atopic dermatitits through regulation of IL-4 in CD4+ cells

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Title
Effect of cinnamamides on atopic dermatitits through regulation of IL-4 in CD4+ cells
Author(s)
E J Choi; Young Bae Ryu; Y Tang; Bo Ram Kim; Woo Song Lee; T Debnath; M Fan; E K Kim; H S Lee
Bibliographic Citation
Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, no. 1, pp. 613-619
Publication Year
2019
Abstract
This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum immunoglobulin (Ig) levels and expression of T-helper (Th)1/Th2 cytokines. Moreover, cinnamamides suppressed interleukin (IL)-4, which plays a crucial role in preparing naive clusters of differentiation (CD)4+ T cells, and decreased the cervical lymph node size and weight. Interestingly, in almost all cases, NCPA exhibited higher anti-AD activity compared to NCT. These results strongly indicate that NCPA may have potential as an anti-AD agent, and further mechanistic comparative studies of NCT and NCPA are required to determine the cause of differences in biological activity.
Keyword
Atopic dermatitisCD4+ T cellsIL-4Th1/Th2 cytokinescinnamamides
ISSN
1475-6366
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14756366.2019.1569647
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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