Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis = ARPC2 저해제인 벤프로페린의 암 전이 효과

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dc.contributor.authorYae Jin Yoon-
dc.contributor.authorYoung-Min Han-
dc.contributor.authorJiyeon Choi-
dc.contributor.authorYu Jin Lee-
dc.contributor.authorJieun Yun-
dc.contributor.authorSu-Kyung Lee-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorSeung-Wook Chi-
dc.contributor.authorJeong Hee Moon-
dc.contributor.authorSangku Lee-
dc.contributor.authorDong Cho Han-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2019-04-09T16:30:13Z-
dc.date.available2019-04-09T16:30:13Z-
dc.date.issued2019-
dc.identifier.issn0006-2952-
dc.identifier.uri10.1016/j.bcp.2019.01.017ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18433-
dc.description.abstractMetastasis is the leading cause of cancer mortality and cancer cell migration is an essential stage of metastasis. We identified benproperine (Benp, a clinically used antitussive drug) as an inhibitor of cancer cell migration and an anti-metastatic agent. Benp selectively inhibited cancer cell migration and invasion, which also suppressed metastasis of cancer cells in animal models. Actin-related protein 2/3 complex subunit 2 (ARPC2) was identified as a molecular target of Benp by affinity column chromatography with Benp-tagged Sepharose beads. Benp bound directly to ARPC2 in cells, which was validated by pull-down assay using Benp-biotin and label-free biochemical methods such as the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA). Benp inhibited Arp2/3 function, showing disruption of lamellipodial structure and inhibition of actin polymerization. Unlike Arp2/3 inhibitors, Benp selectively inhibited the migration of cancer cells but not normal cells. ARPC2-knockdown cancer cells showed defective cell migration and suppressed metastasis in an animal model. Therefore, ARPC2 is a potential target for anti-metastatic therapy, and Benp has the clinical potential to block metastasis. Furthermore, Benp is a useful agent for studying the functions of the Arp2/3 complex in cancer cell migration and metastasis.-
dc.publisherElsevier-
dc.titleBenproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis = ARPC2 저해제인 벤프로페린의 암 전이 효과-
dc.title.alternativeBenproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis-
dc.typeArticle-
dc.citation.titleBiochemical Pharmacology-
dc.citation.number1-
dc.citation.endPage59-
dc.citation.startPage46-
dc.citation.volume163-
dc.contributor.affiliatedAuthorYae Jin Yoon-
dc.contributor.affiliatedAuthorYoung-Min Han-
dc.contributor.affiliatedAuthorJiyeon Choi-
dc.contributor.affiliatedAuthorYu Jin Lee-
dc.contributor.affiliatedAuthorSu-Kyung Lee-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorSeung-Wook Chi-
dc.contributor.affiliatedAuthorJeong Hee Moon-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName윤예진-
dc.contributor.alternativeName한영민-
dc.contributor.alternativeName최지연-
dc.contributor.alternativeName이유진-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName이수경-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName지승욱-
dc.contributor.alternativeName문정희-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationBiochemical Pharmacology, vol. 163, no. 1, pp. 46-59-
dc.identifier.doi10.1016/j.bcp.2019.01.017-
dc.subject.keywordARPC2-
dc.subject.keywordArp2/3 complex-
dc.subject.keywordBenproperine-
dc.subject.keywordDrug repurposing-
dc.subject.keywordMetastasis-
dc.subject.localARPC2-
dc.subject.localArp2/3 complex-
dc.subject.localBenproperine-
dc.subject.localDrug Repurposing-
dc.subject.localdrug repurposing-
dc.subject.localDrug repurposing-
dc.subject.localmetastasis-
dc.subject.localMetastasis-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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