Biotransformation of dicarboxylic acids from vegetable oil-derived sources: current methods and suggestions for improvement

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Title
Biotransformation of dicarboxylic acids from vegetable oil-derived sources: current methods and suggestions for improvement
Author(s)
Heeseok Lee; Y E C Sugiharto; Hyeokwon LeeWooyoung JeonJungoh AhnHong-Weon Lee
Bibliographic Citation
Applied Microbiology and Biotechnology, vol. 103, no. 4, pp. 1545-1555
Publication Year
2019
Abstract
Sustainable manufacture of dicarboxylic acids (DCAs), which are used as raw materials for multiple commercial products, has been an area of considerable research interest in recent years. Traditional chemical-based manufacture of DCAs suffers from limitations such as harsh operational conditions and generation of hazardous by-products. Microbiological methods involving DCA production depend on the capability of alkane-assimilating microorganisms, particularly α, ω-oxidation, to metabolize alkanes. Alkanes are still used as the most common substrates for this method, but the use of renewable resources, such as vegetable oil-derived fatty acid methyl esters (FAMEs), offers multiple advantages for the sustainable production of DCA. However, DCA production using FAME, unlike that using alkanes, still has low productivity and process stability, and we have attempted to identify several limiting factors that weaken the competitiveness. This review discusses the current status and suggests solutions to various obstacles to improve the biotransformation process of FAMEs.
Keyword
BiotransformationDicarboxylic acidsFatty acid methyl estersFatty acid toxicityRenewable resourcesω-Oxidation
ISSN
0175-7598
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00253-018-9571-7
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
Division of Bio Technology Innovation > 1. Journal Articles
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