Causes and mechanisms of hematopoietic stem cell aging

Cited 39 time in scopus
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Title
Causes and mechanisms of hematopoietic stem cell aging
Author(s)
Jungwoon LeeSuk Ran Yoon; In Pyo Choi; Haiyoung Jung
Bibliographic Citation
International Journal of Molecular Sciences, vol. 20, no. 6, pp. 1272-1272
Publication Year
2019
Abstract
Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells throughout the lifetime of an organism. Recent reports have suggested that HSCs are susceptible to age-related stress and gradually lose their self-renewal and regeneration capacity with aging. HSC aging is driven by cell-intrinsic and -extrinsic factors that result in the disruption of the immune system. Thus, the study of HSC aging is important to our understanding of age-related immune diseases and can also provide potential strategies to improve quality of life in the elderly. In this review, we delineate our understanding of the phenotypes, causes, and molecular mechanisms involved in HSC aging.
Keyword
differentiationhematopoietic stem cell agingrejuvenationself-renewal
ISSN
1422-0067
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms20061272
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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