Bioinformatic analysis of regulation of natural antisense transcripts by transposable elements in human mRNA

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Title
Bioinformatic analysis of regulation of natural antisense transcripts by transposable elements in human mRNA
Author(s)
Jaeeun Jung; Sugi Lee; Hyun Soo ChoKunhyang Park; Jea Woon Ryu; Minah Jung; Jeongkil Kim; Hyeran KimDae Soo Kim
Bibliographic Citation
Genomics, vol. 111, no. 2, pp. 159-166
Publication Year
2019
Abstract
Non-coding RNA is no longer considered to be "junk" DNA, based on evidence uncovered in recent decades. In particular, the important role played by natural antisense transcripts (NATs) in regulating the expression of genes is receiving increasing attention. However, the regulatory mechanisms of NATs remain incompletely understood. It is well-known that the insertion of transposable elements (TEs) can affect gene transcription. Using a bioinformatics approach, we identified NATs using human mRNA sequences from the UCSC Genome Browser Database. Our in silico analysis identified 1079 NATs and 700 sense-antisense gene pairs. We identified 179 NATs that showed evidence of having been affected by TEs during cellular gene expression. These findings may provide an understanding of the complex regulation mechanisms of NATs. If our understanding of NATs as modulators of gene expression is further enhanced, we can develop ways to control gene expression.
Keyword
BioinformaticsHuman mRNAsNatural antisense transcriptsTransposable elements
ISSN
0888-7543
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ygeno.2018.01.011
Type
Article
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Bio Technology Innovation > Core Facility Management Center > 1. Journal Articles
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