Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer

Cited 3 time in scopus
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Title
Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer
Author(s)
Yun-Ji Jeung; K Lee; H J Lee; Eunah Kim; Myung Jin SonJiwon Ahn; Han-Gyeul Kim; Wantae Kim; Ho-Joon Lee; J M Kim; Kyung-Sook Chung
Bibliographic Citation
Cancer Science, vol. 110, no. 4, pp. 1453-1463
Publication Year
2019
Abstract
Tumor cells overexpress amino acid transporters to meet the increased demand for amino acids. PQ loop repeat-containing (PQLC)2 is a cationic amino acid transporter that might be involved in cancer progression. Here, we show that upregulation of PQLC2 is critical to gastric cancer (GC) development in vitro and in vivo. Both PQLC2 mRNA and protein were overexpressed in GC tissues, especially of the diffuse type. Overexpression of PQLC2 promoted cell growth, anchorage independence, and tumor formation in nude mice. This was due to activation of MEK/ERK1/2 and PI3K/AKT signaling. Conversely, PQLC2 knockdown caused growth arrest and cell death of cancer cells and suppressed tumor growth in a mouse xenograft model. These results suggest that targeting PQLC2 is an effective strategy for GC treatment.
Keyword
gastric cancermetastasisPQLC2therapeutic targettumor formation
ISSN
1347-9032
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/cas.13966
Type
Article
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Research on National Challenges > 1. Journal Articles
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