Cited 3 time in
- Prediagnostic smoking and alcohol drinking and gastric cancer survival: a Korean prospective cohort study = 진단 전 흡연과 음주 행태와 위암 환자의 생존율: 전향적 환자 코호트 연구
- S A Kim; B Y Choi; K S Song; C H Park; C S Eun; D S Han; Yong Sung Kim; H J Kim
- Bibliographic Citation
- Korean Journal of Gastroenterology, vol. 73, no. 3, pp. 141-151
- Publication Year
- Background/Aims: Behavioral factors, such as smoking and heavy alcohol consumption, increase the risk of gastric cancer (GC), but
their effects on survival are not clear. We examined associations between prediagnostic smoking and alcohol drinking behavior and
GC death by long-term follow-up.
Methods: The participants were 508 GC patients enrolled at Chungnam University Hospital and Hanyang University Guri Hospital from
2001 to 2006. Information on clinicopathologic and behavioral risk factors was collected, and patient survival was prospectively followed
until 2016 by medical chart review and telephone survey.
Results: During above 10 years follow-up period, overall death was 46.2% (n=226) and GC deaths was 38.2% (n=187) among the
489 GC patients included in the analysis. No significant association was found between smoking habits and overall or GC survival. However,
after stratification by histological type, the hazard ratio (HR) of GC death for current smokers tended to be higher for the diffuse type (HR
1.61, 95% CI 0.57-4.59 for current vs. never) rather than for the intestinal type (HR 0.78, 95% CI 0.28-2.19 for current vs. never). Light
alcohol consumption was found to be associated with a significantly lower risk of GC death (HR 0.52, 95% CI 0.36-0.75 for <20 g/day
for women or <40 g/day for men vs. never and past), and the effects of alcohol drinking habits had similar effects on GC death for the
intestinal and diffuse types.
Conclusions: These results suggest smoking and alcohol drinking behaviors before a diagnosis of GC are weakly associated with GC
survival. Nevertheless, the effect of smoking behavior on prognosis appears to depend on the histological type of GC. (Korean J
- Stomach neoplasms; Survival; Smoking; Drinking; Prospective studies
- South Korea
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- Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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