Melatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho

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dc.contributor.authorJ W Ko-
dc.contributor.authorN R Shin-
dc.contributor.authorT Y Jung-
dc.contributor.authorI S Shin-
dc.contributor.authorC Moon-
dc.contributor.authorS H Kim-
dc.contributor.authorIn Chul Lee-
dc.contributor.authorS H Kim-
dc.contributor.authorWoon Kee Yoon-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorJ C Kim-
dc.date.accessioned2019-07-10T01:23:15Z-
dc.date.available2019-07-10T01:23:15Z-
dc.date.issued2019-
dc.identifier.issn02786915-
dc.identifier.uri10.1016/j.fct.2019.04.049ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18730-
dc.description.abstractThis study investigated the protective effects of melatonin (MT) against cisplatin (CP)-induced acute kidney injury in rats as well as its possible mechanism of action associated with anti-aging protein Klotho. The following four experimental groups were evaluated: vehicle control, CP (7 mg/kg), CP&MT20 (20 mg/kg/day), and CP&MT40 (40 mg/kg/day). The concomitant administration of MT significantly ameliorated CP-induced acute kidney injury in rats, as evidenced by increased kidney weight, increased serum levels of blood urea nitrogen and creatinine, and increased incidence of histopathological alterations with renal tubular cell apoptosis. In addition, MT treatment protected kidney tissue against oxidative damages and significantly upregulated the expression level of Klotho decreased by CP treatment, resulting in reduced phosphorylation of protein kinase B (AKT) and forkhead box O (FOXO) as well as reduced expression levels of B-cell lymphoma 2-associated X protein (Bax) and caspase-3. MT not only partially regulated oxidative stress via AKT/FOXO signaling, but also reduced apoptosis caused by CP by inhibiting the Bax/caspase-3 pathway. Our results indicated that MT could prevent acute kidney injury induced by CP in rats, presumably through upregulating the expression of Klotho, resulting in elevated anti-oxidant and anti-apoptotic properties.-
dc.publisherElsevier-
dc.titleMelatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho-
dc.title.alternativeMelatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho-
dc.typeArticle-
dc.citation.titleFood and Chemical Toxicology-
dc.citation.number0-
dc.citation.endPage210-
dc.citation.startPage201-
dc.citation.volume129-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.affiliatedAuthorWoon Kee Yoon-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName고제원-
dc.contributor.alternativeName신나래-
dc.contributor.alternativeName정태양-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName문창종-
dc.contributor.alternativeName김성호-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName김종춘-
dc.identifier.bibliographicCitationFood and Chemical Toxicology, vol. 129, pp. 201-210-
dc.identifier.doi10.1016/j.fct.2019.04.049-
dc.subject.keywordCisplatin-
dc.subject.keywordAcute kidney injury-
dc.subject.keywordMelatonin-
dc.subject.keywordProtective effect-
dc.subject.keywordKlotho-
dc.subject.localCisplatin-
dc.subject.localAcute kidney injury-
dc.subject.localMelatonin-
dc.subject.localProtective effect-
dc.subject.localKlotho-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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