Protein tyrosine phosphatase, receptor type B (PTPRB) inhibits brown adipocyte differentiation through regulation of VEGFR2 phosphorylation

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dc.contributor.authorJi Soo Kim-
dc.contributor.authorWon Kon Kim-
dc.contributor.authorKyoung Jin Oh-
dc.contributor.authorEun Woo Lee-
dc.contributor.authorBaek Soo Han-
dc.contributor.authorSang Chul Lee-
dc.contributor.authorKwang-Hee Bae-
dc.date.accessioned2019-07-10T01:23:20Z-
dc.date.available2019-07-10T01:23:20Z-
dc.date.issued2019-
dc.identifier.issn1017-7825-
dc.identifier.uri10.4014/jmb.1810.10033ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18750-
dc.description.abstractBrown adipocytes have an important role in the regulation of energy balance through uncoupling protein-1 (UCP-1)-mediated nonshivering thermogenesis. Although brown adipocytes have been highlighted as a new therapeutic target for the treatment of metabolic diseases, such as obesity and type II diabetes in adult humans, the molecular mechanism underlying brown adipogenesis is not fully understood. We recently found that protein tyrosine phosphatase receptor type B (PTPRB) expression dramatically decreased during brown adipogenic differentiation. In this study, we investigated the functional roles of PTPRB and its regulatory mechanism during brown adipocyte differentiation. Ectopic expression of PTPRB led to a reduced brown adipocyte differentiation by suppressing the tyrosine phosphorylation of VEGFR2, whereas a catalytic inactive PTPRB mutant showed no effects on differentiation and phosphorylation. Consistently, the expression of brown adipocyte-related genes, such as UCP-1, PGC-1α, PRDM16, PPAR-γ, and CIDEA, were significantly inhibited by PTPRB overexpression. Overall, these results suggest that PTPRB functions as a negative regulator of brown adipocyte differentiation through its phosphatase activity-dependent mechanism and may be used as a target protein for the regulation of obesity and type II diabetes.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleProtein tyrosine phosphatase, receptor type B (PTPRB) inhibits brown adipocyte differentiation through regulation of VEGFR2 phosphorylation-
dc.title.alternativeProtein tyrosine phosphatase, receptor type B (PTPRB) inhibits brown adipocyte differentiation through regulation of VEGFR2 phosphorylation-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number4-
dc.citation.endPage650-
dc.citation.startPage645-
dc.citation.volume29-
dc.contributor.affiliatedAuthorJi Soo Kim-
dc.contributor.affiliatedAuthorWon Kon Kim-
dc.contributor.affiliatedAuthorKyoung Jin Oh-
dc.contributor.affiliatedAuthorEun Woo Lee-
dc.contributor.affiliatedAuthorBaek Soo Han-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName오경진-
dc.contributor.alternativeName이은우-
dc.contributor.alternativeName한백수-
dc.contributor.alternativeName이상철-
dc.contributor.alternativeName배광희-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 29, no. 4, pp. 645-650-
dc.identifier.doi10.4014/jmb.1810.10033-
dc.subject.keywordBrown adipogenesis-
dc.subject.keywordobesity-
dc.subject.keywordPTPRB-
dc.subject.keywordVEGFR2-
dc.subject.localBrown adipogenesis-
dc.subject.localbrown adipogenesis-
dc.subject.localObesity-
dc.subject.localobesity-
dc.subject.localPTPRB-
dc.subject.localVEGFR2-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
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