Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

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Title
Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression
Author(s)
H J Lee; Yeonghoon Son; M Lee; C Moon; S H Kim; I S Shin; M Yang; S Bae; J S Kim
Bibliographic Citation
Neural Regeneration Research, vol. 14, no. 9, pp. 1530-1535
Publication Year
2019
Abstract
Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences (approval No. KIRAMS16-0002) on December 30, 2016.
Keyword
sodium butyrateradioprotectorionizing radiationhippocampal damagecAMP response element bindingbrain-derived neurotrophic factorhistone deacetylase inhibitorneurogenesis
ISSN
1673-5374
Publisher
Kluwer
DOI
http://dx.doi.org/10.4103/1673-5374.255974
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
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