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- In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity
- Hyung Jin Lim; Hyun Jae Jang; Seon Gyeong Bak; Soyoung Lee; Seung Woong Lee; K M Lee; Seung Jae Lee; Mun Chual Rho
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 29, no. 13, pp. 1586-1592
- Publication Year
- Many studies have identified and described various medicinal effects of cirsiliol. Here, we investigated the signaling pathway involved in the anti-inflammatory effects of cirsiliol on IL-6-induced activity. Cirsiliol showed no cytotoxicity and inhibited pSTAT3-induced luciferase activity. At the molecular level, cirsiliol suppressed the expression of IL-6-induced inflammatory marker genes such as CRP, IL-1β, ICAM-1 and SOCS3, IL-6-induced activation of Jak2, gp130, STAT3 and ERK and nuclear translocation of STAT3, as measured by PCR, immunofluorescence staining and western blot analysis. However, the interaction between IL-6 and its receptor was not affected by cirsiliol treatment. These results indicate that cirsiliol attenuates IL-6-induced cellular signaling by regulating Jak2 phosphorylation. Therefore, cirsiliol could be a therapeutic agent for IL-6-related inflammatory diseases.
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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