Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes = 세드렐라 오도라타의 Keratinocyte 세포에서의 항염증 효과

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Title
Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes = 세드렐라 오도라타의 Keratinocyte 세포에서의 항염증 효과
Author(s)
Han-Sol Lee; Ji Won Park; Ok-Kyoung Kwon; Yourim Lim; Jung Hee KimSoo Yong Kim; N Zamora; K Rosales; Sangho ChoiSei-Ryang OhKyung Seop Ahn
Bibliographic Citation
Experimental and Therapeutic Medicine, vol. 18, pp. 833-840
Publication Year
2019
Abstract
Cedrela odorata L. is a native plant of the Amazon region. The bark is used in folk remedies for the treatment of diarrhea, vomiting, fever and inflammation. Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease accompanied by itching. It is a complex disease involving environmental factors and genetic factors. In the present study, the anti-inflammatory and anti-allergic effects of C. odorata L. methanol extract (COEE) on tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated HaCaT keratinocyte cells were investigated. ELISA and RT-PCR analysis revealed that the extract had anti-inflammatory effects, and reduced the interleukin (IL)-6 and IL-8 levels of the HaCaT cells. In addition, COEE exhibited anti-allergic effects, comprising a reduction in the thymus and activation-regulated chemokine and macrophage-derived chemokine levels. In addition, pathway analysis and comparison with Bay11-7082 indicated that these effects are due to the inhibition of nuclear factor (NF)-κB in TNF-α/IFN-γ-induced HaCaT cells. Therefore, the results of the present study suggest that COEE has anti-inflammatory and anti-allergic properties in TNF-α and IFN-γ-stimulated HaCaT cells, which are associated with the inhibition of pro-inflammatory cytokines and chemokines via the NF-κB pathway.
Keyword
Cedrela odorataAnti-inflammationAtopic dermatitisChemokinePro-inflammatory cytokine
ISSN
1792-0981
Publisher
Spandidos Publ Ltd
DOI
http://dx.doi.org/10.3892/etm.2019.7639
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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