MicroRNAs in skeletal muscle aging: current issues and perspectives = 근육노화에서 마이크로 RNA의 역할

Cited 18 time in scopus
Metadata Downloads
Title
MicroRNAs in skeletal muscle aging: current issues and perspectives = 근육노화에서 마이크로 RNA의 역할
Author(s)
H J Jung; Kwang-Pyo LeeKi-Sun Kwon; Y Suh
Bibliographic Citation
Journals of Gerontology Series A-Biological Sciences and Medical Sciences, vol. 74, no. 7, pp. 1008-1014
Publication Year
2019
Abstract
Skeletal muscle is one of the major organs responsible for body movements and metabolism making up approximately 40% of the total body mass. During aging, skeletal muscle exhibits a degenerative age-associated decline in mass and function termed sarcopenia. This age-associated dysfunction of skeletal muscle is a major criterion of morbidity, mortality, and overall declines of quality of life in the elderly people. Therefore, researchers have focused on identifying modulators of muscle aging process including messenger RNAs, proteins, and recently small noncoding RNAs such as microRNAs (miRNAs). In particular, miRNAs have been demonstrated to play a critical role in skeletal muscle development and homeostasis. Recent studies revealed that miRNAs were also involved in muscle aging processes and the rejuvenation of aged muscle by regulating important molecules and pathways of aging including insulin-like growth factors, nicotine-adenine dinucleotide (+)-dependent protein deacetylase sirtuin-1, telomerase reverse transcriptase, and transforming growth factor-β signaling pathway. Over the years, miRNAs have emerged as promising candidates for biomarkers of sarcopenia and targets for interventions to slow muscle aging. Here, we comprehensively review the current knowledge on the role of miRNAs in skeletal muscle aging and highlight their potential as biomarkers or therapeutic targets for skeletal muscle health.
Keyword
MicroRNASkeletal muscleSarcopeniaMuscle agingMuscle stem cells
ISSN
1079-5006
Publisher
Oxford Univ Press
DOI
http://dx.doi.org/10.1093/gerona/gly207
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.