Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells

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dc.contributor.authorMyung-Ji Kang-
dc.contributor.authorSoo Yeon Kim-
dc.contributor.authorEun-Bin Kwon-
dc.contributor.authorYang Hee Jo-
dc.contributor.authorM K Lee-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorD O Moon-
dc.contributor.authorMun-Ock Kim-
dc.date.accessioned2019-07-10T01:23:37Z-
dc.date.available2019-07-10T01:23:37Z-
dc.date.issued2019-
dc.identifier.issn1932-6203-
dc.identifier.uri10.1371/journal.pone.0218659ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18827-
dc.description.abstractWe studied the effect of derrone (DR), one of the major compounds of unripe fruits of Cudrania tricuspidata, on cancer cell death. DR inhibited cell growth of various cancer cells, and that was partially associated with apoptosis in A549 cells. DR showed the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62). The treatment of autophagy inhibitor reversed DRmediated cell death, suggesting that DR induces autophagic cell death. The increase of cytoplasmic Ca2+ and ROS by DR treatment significantly influences the formation of autophagosomes; however, only ROS scavengers significantly rescued the reduced cell viability. Additional results revealed that treatment of DR induces sustained phosphorylation of ERK and the inhibition of ERK phosphorylation using U0126 (ERK inhibitor) markedly attenuated DR-induced cell death. Overall, these results suggest that DR induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells.-
dc.publisherPublic Library of Science-
dc.titleDerrone induces autophagic cell death through induction of ROS and ERK in A549 cells-
dc.title.alternativeDerrone induces autophagic cell death through induction of ROS and ERK in A549 cells-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number6-
dc.citation.endPagee0218659-
dc.citation.startPagee0218659-
dc.citation.volume14-
dc.contributor.affiliatedAuthorMyung-Ji Kang-
dc.contributor.affiliatedAuthorSoo Yeon Kim-
dc.contributor.affiliatedAuthorEun-Bin Kwon-
dc.contributor.affiliatedAuthorYang Hee Jo-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorMun-Ock Kim-
dc.contributor.alternativeName강명지-
dc.contributor.alternativeName김수연-
dc.contributor.alternativeName권은빈-
dc.contributor.alternativeName조양희-
dc.contributor.alternativeName이미경-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName문동오-
dc.contributor.alternativeName김문옥-
dc.identifier.bibliographicCitationPLoS One, vol. 14, no. 6, pp. e0218659-e0218659-
dc.identifier.doi10.1371/journal.pone.0218659-
dc.description.journalClassY-
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Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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