Indoleamine-2,3-dioxygenase in thyroid cancer cells suppresses natural killer cell function by inhibiting NKG2D and NKp46 expression via STAT signaling pathways

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dc.contributor.authorArum Park-
dc.contributor.authorYunjeong Yang-
dc.contributor.authorYunhee Lee-
dc.contributor.authorMi Sun Kim-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorHaiyoung Jung-
dc.contributor.authorTae-Don Kim-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorIn Pyo Choi-
dc.contributor.authorSuk Ran Yoon-
dc.date.accessioned2019-07-10T01:23:38Z-
dc.date.available2019-07-10T01:23:38Z-
dc.date.issued2019-
dc.identifier.issn2077-0383-
dc.identifier.uri10.3390/jcm8060842ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18829-
dc.description.abstractNatural killer (NK) cells are key players in the immune system. They use receptors on their cell surface to identify target cells. However, to escape being killed by the immune system, cancer cells such as thyroid cancer cells, use various methods to suppress the function of NK cells. Thus, this study aims to elucidate how thyroid cancer cells downregulate NK cell function in a co-culture system. We found that thyroid cancer cells suppress NK cell cytotoxicity and inhibit the expression of activating receptors, such as NKG2D and NKp46, by regulating indoleamine 2,3-dioxygenase (IDO). Also, thyroid cancer cells produce kynurenine using IDO, which causes NK cell dysfunction. Kynurenine enters NK cells via the aryl hydrocarbon receptor (AhR) on the surfaces of the NK cells, which decreases NK cell function and NK receptor expression via the signal transducer and activator of transcription (STAT) 1 and STAT3 pathways. In addition, STAT1 and STAT3 directly regulated the expression of NKG2D and NKp46 receptors by binding to the promoter region. Conclusively, NK cell function may be impaired in thyroid cancer patients by IDO-induced kynurenine production. This implies that IDO can be used as a target for thyroid cancer therapeutics aiming at improving NK cell function.-
dc.publisherMDPI-
dc.titleIndoleamine-2,3-dioxygenase in thyroid cancer cells suppresses natural killer cell function by inhibiting NKG2D and NKp46 expression via STAT signaling pathways-
dc.title.alternativeIndoleamine-2,3-dioxygenase in thyroid cancer cells suppresses natural killer cell function by inhibiting NKG2D and NKp46 expression via STAT signaling pathways-
dc.typeArticle-
dc.citation.titleJournal of Clinical Medicine-
dc.citation.number6-
dc.citation.endPage842-
dc.citation.startPage842-
dc.citation.volume8-
dc.contributor.affiliatedAuthorArum Park-
dc.contributor.affiliatedAuthorYunjeong Yang-
dc.contributor.affiliatedAuthorYunhee Lee-
dc.contributor.affiliatedAuthorMi Sun Kim-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorTae-Don Kim-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.alternativeName박아름-
dc.contributor.alternativeName양윤정-
dc.contributor.alternativeName이윤희-
dc.contributor.alternativeName김미선-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName김태돈-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName윤석란-
dc.identifier.bibliographicCitationJournal of Clinical Medicine, vol. 8, no. 6, pp. 842-842-
dc.identifier.doi10.3390/jcm8060842-
dc.subject.keywordNK cells-
dc.subject.keywordthyroid cancer cells-
dc.subject.keywordindoleamine 2,3-dioxygenase-
dc.subject.keywordkynurenine-
dc.subject.keywordNKG2D-
dc.subject.keywordNKp46-
dc.subject.keywordSTAT1-
dc.subject.keywordSTAT 3-
dc.subject.localNK cells-
dc.subject.localNK cell-
dc.subject.localthyroid cancer cells-
dc.subject.localIndoleamine 2,3-dioxygenase (IDO)-
dc.subject.localindoleamine 2,3-dioxygenase-
dc.subject.localIndoleamine-2,3-dioxygenase-
dc.subject.localindoleamine 2,3-dioxygenase (IDO)-
dc.subject.localkynurenine-
dc.subject.localNKG2D-
dc.subject.localNKp46-
dc.subject.localSTAT1-
dc.subject.localSTAT-1-
dc.subject.localSignal transducer and activator of transcription 3 (STAT3)-
dc.subject.localSignal transducer and activator of transcription-
dc.subject.localSignal transducer and activator of transcription 3 (Stat3)-
dc.subject.localSTAT 3-
dc.subject.localSTAT3-
dc.subject.localSignal transducer and activator of transcription 3-
dc.subject.localStat3-
dc.subject.localSignal transducer and activator of transcription factor 3 (STAT3)-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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