Abnormal mitochondria in a non-human primate model of MPTP-induced Parkinson's disease: Drp1 and CDK5/p25 signaling = 원숭이 파킨슨병 모델 뇌조직내 미토콘드리아 손상이 Drp1과 CDK5/p25 신호전달과 관련

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dc.contributor.authorJunghyung Park-
dc.contributor.authorJincheol Seo-
dc.contributor.authorJinyoung Won-
dc.contributor.authorHyeon-Gu Yeo-
dc.contributor.authorYu-Jin Ahn-
dc.contributor.authorKeonwoo Kim-
dc.contributor.authorYeung Bae Jin-
dc.contributor.authorBon Sang Koo-
dc.contributor.authorKyung Seob Lim-
dc.contributor.authorKang Jin Jeong-
dc.contributor.authorPhilyong Kang-
dc.contributor.authorHwal Yong Lee-
dc.contributor.authorSeung Ho Baek-
dc.contributor.authorChang Yeop Jeon-
dc.contributor.authorJung Joo Hong-
dc.contributor.authorJae Won Huh-
dc.contributor.authorYoung-Hyun Kim-
dc.contributor.authorSang Je Park-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorD S Lee-
dc.contributor.authorSang-Rae Lee-
dc.contributor.authorYoungjeon Lee-
dc.date.accessioned2019-10-28T16:30:08Z-
dc.date.available2019-10-28T16:30:08Z-
dc.date.issued2019-
dc.identifier.issn1226-2560-
dc.identifier.uri10.5607/en.2019.28.3.414ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18874-
dc.description.abstractMitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is related to neurodegenerative diseases such as Parkinson's disease (PD), with excessive mitochondrial fission in dopaminergic neurons being one of the pathological mechanisms of PD. Here, we investigated the balance between mitochondrial fusion and fission in the substantia nigra of a non-human primate model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD. We found that MPTP induced shorter and abnormally distributed mitochondria. This phenomenon was accompanied by the activation of dynamin-related protein 1 (Drp1), a mitochondrial fission protein, through increased phosphorylation at S616. Thereafter, we assessed for activation of the components of the cyclin-dependent kinase 5 (CDK5) and extracellular signal-regulated kinase (ERK) signaling cascades, which are known regulators of Drp1(S616) phosphorylation. MPTP induced an increase in p25 and p35, which are required for CDK5 activation. Together, these findings suggest that the phosphorylation of Drp1(S616) by CDK5 is involved in mitochondrial fission in the substantia nigra of a non-human primate model of MPTP-induced PD.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleAbnormal mitochondria in a non-human primate model of MPTP-induced Parkinson's disease: Drp1 and CDK5/p25 signaling = 원숭이 파킨슨병 모델 뇌조직내 미토콘드리아 손상이 Drp1과 CDK5/p25 신호전달과 관련-
dc.title.alternativeAbnormal mitochondria in a non-human primate model of MPTP-induced Parkinson's disease: Drp1 and CDK5/p25 signaling-
dc.typeArticle-
dc.citation.titleExperimental Neurobiology-
dc.citation.number3-
dc.citation.endPage424-
dc.citation.startPage414-
dc.citation.volume28-
dc.contributor.affiliatedAuthorJunghyung Park-
dc.contributor.affiliatedAuthorJincheol Seo-
dc.contributor.affiliatedAuthorJinyoung Won-
dc.contributor.affiliatedAuthorHyeon-Gu Yeo-
dc.contributor.affiliatedAuthorYu-Jin Ahn-
dc.contributor.affiliatedAuthorKeonwoo Kim-
dc.contributor.affiliatedAuthorYeung Bae Jin-
dc.contributor.affiliatedAuthorBon Sang Koo-
dc.contributor.affiliatedAuthorKyung Seob Lim-
dc.contributor.affiliatedAuthorKang Jin Jeong-
dc.contributor.affiliatedAuthorPhilyong Kang-
dc.contributor.affiliatedAuthorHwal Yong Lee-
dc.contributor.affiliatedAuthorSeung Ho Baek-
dc.contributor.affiliatedAuthorChang Yeop Jeon-
dc.contributor.affiliatedAuthorJung Joo Hong-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorYoung-Hyun Kim-
dc.contributor.affiliatedAuthorSang Je Park-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorSang-Rae Lee-
dc.contributor.affiliatedAuthorYoungjeon Lee-
dc.contributor.alternativeName박정형-
dc.contributor.alternativeName서진철-
dc.contributor.alternativeName원진영-
dc.contributor.alternativeName여현구-
dc.contributor.alternativeName안유진-
dc.contributor.alternativeName김건우-
dc.contributor.alternativeName진영배-
dc.contributor.alternativeName구본상-
dc.contributor.alternativeName임경섭-
dc.contributor.alternativeName정강진-
dc.contributor.alternativeName강필용-
dc.contributor.alternativeName이활용-
dc.contributor.alternativeName백승호-
dc.contributor.alternativeName전창엽-
dc.contributor.alternativeName홍정주-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김영현-
dc.contributor.alternativeName박상제-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName이동석-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName이영전-
dc.identifier.bibliographicCitationExperimental Neurobiology, vol. 28, no. 3, pp. 414-424-
dc.identifier.doi10.5607/en.2019.28.3.414-
dc.subject.keywordCyclin-dependent kinases-
dc.subject.keywordMitochondria-
dc.subject.keywordMitochondrial dynamics-
dc.subject.keywordNon-human primate-
dc.subject.keywordParkinson disease-
dc.subject.localCyclin-dependent kinases-
dc.subject.localcyclin-dependent kinase-
dc.subject.localmitochondria-
dc.subject.localMitochondria-
dc.subject.localmitochondrial dynamics-
dc.subject.localMitochondrial dynamics-
dc.subject.localNon-human primate-
dc.subject.localNon-human primates-
dc.subject.localNonhuman primate-
dc.subject.localNonhuman primate (NHP)-
dc.subject.localNonhuman primates-
dc.subject.localnon-human primate-
dc.subject.localnonhuman primates-
dc.subject.localParkinson disease-
dc.subject.localParkinson's disease-
dc.subject.localParkinson’s Disease-
dc.subject.localParkinson’s disease-
dc.subject.localParkinson’s diseases-
dc.subject.localParkinsons disease (PD)-
dc.subject.localParkinsons disease-
dc.subject.localParkinson's diasease-
dc.subject.localParkinson's Disease-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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