DC Field | Value | Language |
---|---|---|
dc.contributor.author | Junghyung Park | - |
dc.contributor.author | Jincheol Seo | - |
dc.contributor.author | Jinyoung Won | - |
dc.contributor.author | Hyeon-Gu Yeo | - |
dc.contributor.author | Yu-Jin Ahn | - |
dc.contributor.author | Keonwoo Kim | - |
dc.contributor.author | Yeung Bae Jin | - |
dc.contributor.author | Bon Sang Koo | - |
dc.contributor.author | Kyung Seob Lim | - |
dc.contributor.author | Kang Jin Jeong | - |
dc.contributor.author | Philyong Kang | - |
dc.contributor.author | Hwal Yong Lee | - |
dc.contributor.author | Seung Ho Baek | - |
dc.contributor.author | Chang Yeop Jeon | - |
dc.contributor.author | Jung Joo Hong | - |
dc.contributor.author | Jae Won Huh | - |
dc.contributor.author | Young-Hyun Kim | - |
dc.contributor.author | Sang Je Park | - |
dc.contributor.author | Sun-Uk Kim | - |
dc.contributor.author | D S Lee | - |
dc.contributor.author | Sang-Rae Lee | - |
dc.contributor.author | Youngjeon Lee | - |
dc.date.accessioned | 2019-10-28T16:30:08Z | - |
dc.date.available | 2019-10-28T16:30:08Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | 10.5607/en.2019.28.3.414 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18874 | - |
dc.description.abstract | Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is related to neurodegenerative diseases such as Parkinson's disease (PD), with excessive mitochondrial fission in dopaminergic neurons being one of the pathological mechanisms of PD. Here, we investigated the balance between mitochondrial fusion and fission in the substantia nigra of a non-human primate model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD. We found that MPTP induced shorter and abnormally distributed mitochondria. This phenomenon was accompanied by the activation of dynamin-related protein 1 (Drp1), a mitochondrial fission protein, through increased phosphorylation at S616. Thereafter, we assessed for activation of the components of the cyclin-dependent kinase 5 (CDK5) and extracellular signal-regulated kinase (ERK) signaling cascades, which are known regulators of Drp1(S616) phosphorylation. MPTP induced an increase in p25 and p35, which are required for CDK5 activation. Together, these findings suggest that the phosphorylation of Drp1(S616) by CDK5 is involved in mitochondrial fission in the substantia nigra of a non-human primate model of MPTP-induced PD. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Abnormal mitochondria in a non-human primate model of MPTP-induced Parkinson's disease: Drp1 and CDK5/p25 signaling = 원숭이 파킨슨병 모델 뇌조직내 미토콘드리아 손상이 Drp1과 CDK5/p25 신호전달과 관련 | - |
dc.title.alternative | Abnormal mitochondria in a non-human primate model of MPTP-induced Parkinson's disease: Drp1 and CDK5/p25 signaling | - |
dc.type | Article | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 424 | - |
dc.citation.startPage | 414 | - |
dc.citation.volume | 28 | - |
dc.contributor.affiliatedAuthor | Junghyung Park | - |
dc.contributor.affiliatedAuthor | Jincheol Seo | - |
dc.contributor.affiliatedAuthor | Jinyoung Won | - |
dc.contributor.affiliatedAuthor | Hyeon-Gu Yeo | - |
dc.contributor.affiliatedAuthor | Yu-Jin Ahn | - |
dc.contributor.affiliatedAuthor | Keonwoo Kim | - |
dc.contributor.affiliatedAuthor | Yeung Bae Jin | - |
dc.contributor.affiliatedAuthor | Bon Sang Koo | - |
dc.contributor.affiliatedAuthor | Kyung Seob Lim | - |
dc.contributor.affiliatedAuthor | Kang Jin Jeong | - |
dc.contributor.affiliatedAuthor | Philyong Kang | - |
dc.contributor.affiliatedAuthor | Hwal Yong Lee | - |
dc.contributor.affiliatedAuthor | Seung Ho Baek | - |
dc.contributor.affiliatedAuthor | Chang Yeop Jeon | - |
dc.contributor.affiliatedAuthor | Jung Joo Hong | - |
dc.contributor.affiliatedAuthor | Jae Won Huh | - |
dc.contributor.affiliatedAuthor | Young-Hyun Kim | - |
dc.contributor.affiliatedAuthor | Sang Je Park | - |
dc.contributor.affiliatedAuthor | Sun-Uk Kim | - |
dc.contributor.affiliatedAuthor | Sang-Rae Lee | - |
dc.contributor.affiliatedAuthor | Youngjeon Lee | - |
dc.contributor.alternativeName | 박정형 | - |
dc.contributor.alternativeName | 서진철 | - |
dc.contributor.alternativeName | 원진영 | - |
dc.contributor.alternativeName | 여현구 | - |
dc.contributor.alternativeName | 안유진 | - |
dc.contributor.alternativeName | 김건우 | - |
dc.contributor.alternativeName | 진영배 | - |
dc.contributor.alternativeName | 구본상 | - |
dc.contributor.alternativeName | 임경섭 | - |
dc.contributor.alternativeName | 정강진 | - |
dc.contributor.alternativeName | 강필용 | - |
dc.contributor.alternativeName | 이활용 | - |
dc.contributor.alternativeName | 백승호 | - |
dc.contributor.alternativeName | 전창엽 | - |
dc.contributor.alternativeName | 홍정주 | - |
dc.contributor.alternativeName | 허재원 | - |
dc.contributor.alternativeName | 김영현 | - |
dc.contributor.alternativeName | 박상제 | - |
dc.contributor.alternativeName | 김선욱 | - |
dc.contributor.alternativeName | 이동석 | - |
dc.contributor.alternativeName | 이상래 | - |
dc.contributor.alternativeName | 이영전 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, vol. 28, no. 3, pp. 414-424 | - |
dc.identifier.doi | 10.5607/en.2019.28.3.414 | - |
dc.subject.keyword | Cyclin-dependent kinases | - |
dc.subject.keyword | Mitochondria | - |
dc.subject.keyword | Mitochondrial dynamics | - |
dc.subject.keyword | Non-human primate | - |
dc.subject.keyword | Parkinson disease | - |
dc.subject.local | Cyclin-dependent kinases | - |
dc.subject.local | cyclin-dependent kinase | - |
dc.subject.local | mitochondria | - |
dc.subject.local | Mitochondria | - |
dc.subject.local | mitochondrial dynamics | - |
dc.subject.local | Mitochondrial dynamics | - |
dc.subject.local | Non-human primate | - |
dc.subject.local | Non-human primates | - |
dc.subject.local | Nonhuman primate | - |
dc.subject.local | Nonhuman primate (NHP) | - |
dc.subject.local | Nonhuman primates | - |
dc.subject.local | non-human primate | - |
dc.subject.local | nonhuman primates | - |
dc.subject.local | Parkinson disease | - |
dc.subject.local | Parkinson's disease | - |
dc.subject.local | Parkinson’s Disease | - |
dc.subject.local | Parkinson’s disease | - |
dc.subject.local | Parkinson’s diseases | - |
dc.subject.local | Parkinsons disease (PD) | - |
dc.subject.local | Parkinsons disease | - |
dc.subject.local | Parkinson's diasease | - |
dc.subject.local | Parkinson's Disease | - |
dc.description.journalClass | Y | - |
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