Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

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dc.contributor.authorK Kim-
dc.contributor.authorOhman Kwon-
dc.contributor.authorTae Young Ryu-
dc.contributor.authorCho Rok Jung-
dc.contributor.authorJanghwan Kim-
dc.contributor.authorJeong Ki Min-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorMi Young Son-
dc.contributor.authorHyun Soo Cho-
dc.date.accessioned2019-10-28T16:30:15Z-
dc.date.available2019-10-28T16:30:15Z-
dc.date.issued2019-
dc.identifier.issn1791-2997-
dc.identifier.uri10.3892/mmr.2019.10431ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18900-
dc.description.abstractShort-chain fatty acids (SCFAs; butyrate, propionate and acetate) are metabolites derived from the gut microbiota via dietary fiber fermentation. In colon cancer, treatment with SCFAs, mainly butyrate and propionate, suppresses cell proliferation, migration and invasion. Furthermore, although sodium butyrate is known to induce cell apoptosis in lung cancer, the anticancer effects of sodium propionate (SP) on lung cancer are not well understood. In the present study, SP treatment induced cell cycle arrest, especially in the G2/M phase, and cell apoptosis in the H1299 and H1703 lung cancer cell lines. As determined by reverse transcription-quantitative PCR and western blotting, Survivin and p21 expression levels were significantly affected by SP treatment, suggesting that SP treatment suppressed cell proliferation in these lung cancer cell lines. Thus, it was proposed that the SP-mediated regulation of Survivin and p21 in lung cancer may be applicable to lung cancer therapy.-
dc.publisherSpandidos Publ Ltd-
dc.titlePropionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer-
dc.title.alternativePropionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer-
dc.typeArticle-
dc.citation.titleMolecular Medicine Reports-
dc.citation.number2-
dc.citation.endPage1574-
dc.citation.startPage1569-
dc.citation.volume20-
dc.contributor.affiliatedAuthorOhman Kwon-
dc.contributor.affiliatedAuthorTae Young Ryu-
dc.contributor.affiliatedAuthorCho Rok Jung-
dc.contributor.affiliatedAuthorJanghwan Kim-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorMi Young Son-
dc.contributor.affiliatedAuthorHyun Soo Cho-
dc.contributor.alternativeName김광교-
dc.contributor.alternativeName권오만-
dc.contributor.alternativeName류태영-
dc.contributor.alternativeName정초록-
dc.contributor.alternativeName김장환-
dc.contributor.alternativeName민정기-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName손미영-
dc.contributor.alternativeName조현수-
dc.identifier.bibliographicCitationMolecular Medicine Reports, vol. 20, no. 2, pp. 1569-1574-
dc.identifier.doi10.3892/mmr.2019.10431-
dc.subject.keywordApoptosis-
dc.subject.keywordCell cycle-
dc.subject.keywordLung cancer-
dc.subject.keywordP21-
dc.subject.keywordPropionate-
dc.subject.keywordSurvivin-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localcell cycle-
dc.subject.localCell cycle-
dc.subject.locallung cancer-
dc.subject.localLung Cancer-
dc.subject.localLung cancer-
dc.subject.localP21-
dc.subject.localp21-
dc.subject.localPropionate-
dc.subject.localSurvivin-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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