DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dong Hyun Kim | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.contributor.author | Ho Jin Han | - |
dc.contributor.author | Hye-Min Kim | - |
dc.contributor.author | Joonsung Hwang | - |
dc.contributor.author | Kyung Ho Lee | - |
dc.contributor.author | Hyunjoo Cha | - |
dc.contributor.author | In Ja Ryoo | - |
dc.contributor.author | Jae-Hyuk Jang | - |
dc.contributor.author | Sung-Kyun Ko | - |
dc.contributor.author | Jin Ok Yang | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | Sangku Lee | - |
dc.contributor.author | E J Song | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | Y H Huh | - |
dc.contributor.author | Y T Kwon | - |
dc.contributor.author | Nak Kyun Soung | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.date.accessioned | 2019-10-28T16:30:17Z | - |
dc.date.available | 2019-10-28T16:30:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | 10.1038/s41419-019-1778-8 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18907 | - |
dc.description.abstract | The initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear. In this study, we demonstrate that Cep131 physically interacts with Plk4 following phosphorylation of residues S21 and T205. Localizing at the centriole, phosphorylated Cep131 has an increased capability to interact with STIL, leading to further activation and stabilization of Plk4 for initiating centrosome duplication. Moreover, we found that Cep131 overexpression resulted in centrosome amplification by excessive recruitment of STIL to the centriole and subsequent stabilization of Plk4, contributing to centrosome amplification. The xenograft mouse model also showed that both centrosome amplification and colon cancer growth were significantly increased by Cep131 overexpression. These findings demonstrate that Cep131 is a novel substrate of Plk4, and that phosphorylation or dysregulated Cep131 overexpression promotes Plk4 stabilization and therefore centrosome amplification, establishing a perspective in understanding a relationship between centrosome amplification and cancer development. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability | - |
dc.title.alternative | Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability | - |
dc.type | Article | - |
dc.citation.title | Cell Death & Disease | - |
dc.citation.number | 8 | - |
dc.citation.endPage | 570 | - |
dc.citation.startPage | 570 | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Dong Hyun Kim | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.affiliatedAuthor | Ho Jin Han | - |
dc.contributor.affiliatedAuthor | Hye-Min Kim | - |
dc.contributor.affiliatedAuthor | Joonsung Hwang | - |
dc.contributor.affiliatedAuthor | Kyung Ho Lee | - |
dc.contributor.affiliatedAuthor | Hyunjoo Cha | - |
dc.contributor.affiliatedAuthor | In Ja Ryoo | - |
dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
dc.contributor.affiliatedAuthor | Sung-Kyun Ko | - |
dc.contributor.affiliatedAuthor | Jin Ok Yang | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.affiliatedAuthor | Sangku Lee | - |
dc.contributor.affiliatedAuthor | Nak Kyun Soung | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.alternativeName | 김동현 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.contributor.alternativeName | 한호진 | - |
dc.contributor.alternativeName | 김혜민 | - |
dc.contributor.alternativeName | 황준성 | - |
dc.contributor.alternativeName | 이경호 | - |
dc.contributor.alternativeName | 차현주 | - |
dc.contributor.alternativeName | 류인자 | - |
dc.contributor.alternativeName | 장재혁 | - |
dc.contributor.alternativeName | 고성균 | - |
dc.contributor.alternativeName | 양진옥 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.contributor.alternativeName | 이상구 | - |
dc.contributor.alternativeName | 송은주 | - |
dc.contributor.alternativeName | 김진영 | - |
dc.contributor.alternativeName | 허양훈 | - |
dc.contributor.alternativeName | 권용태 | - |
dc.contributor.alternativeName | 성낙균 | - |
dc.contributor.alternativeName | 김보연 | - |
dc.identifier.bibliographicCitation | Cell Death & Disease, vol. 10, no. 8, pp. 570-570 | - |
dc.identifier.doi | 10.1038/s41419-019-1778-8 | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.