Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability

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dc.contributor.authorDong Hyun Kim-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorHo Jin Han-
dc.contributor.authorHye-Min Kim-
dc.contributor.authorJoonsung Hwang-
dc.contributor.authorKyung Ho Lee-
dc.contributor.authorHyunjoo Cha-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorJin Ok Yang-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorSangku Lee-
dc.contributor.authorE J Song-
dc.contributor.authorJ Y Kim-
dc.contributor.authorY H Huh-
dc.contributor.authorY T Kwon-
dc.contributor.authorNak Kyun Soung-
dc.contributor.authorBo Yeon Kim-
dc.date.accessioned2019-10-28T16:30:17Z-
dc.date.available2019-10-28T16:30:17Z-
dc.date.issued2019-
dc.identifier.issn20414889-
dc.identifier.uri10.1038/s41419-019-1778-8ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18907-
dc.description.abstractThe initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear. In this study, we demonstrate that Cep131 physically interacts with Plk4 following phosphorylation of residues S21 and T205. Localizing at the centriole, phosphorylated Cep131 has an increased capability to interact with STIL, leading to further activation and stabilization of Plk4 for initiating centrosome duplication. Moreover, we found that Cep131 overexpression resulted in centrosome amplification by excessive recruitment of STIL to the centriole and subsequent stabilization of Plk4, contributing to centrosome amplification. The xenograft mouse model also showed that both centrosome amplification and colon cancer growth were significantly increased by Cep131 overexpression. These findings demonstrate that Cep131 is a novel substrate of Plk4, and that phosphorylation or dysregulated Cep131 overexpression promotes Plk4 stabilization and therefore centrosome amplification, establishing a perspective in understanding a relationship between centrosome amplification and cancer development.-
dc.publisherSpringer-Nature Pub Group-
dc.titleCep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability-
dc.title.alternativeCep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability-
dc.typeArticle-
dc.citation.titleCell Death & Disease-
dc.citation.number8-
dc.citation.endPage570-
dc.citation.startPage570-
dc.citation.volume10-
dc.contributor.affiliatedAuthorDong Hyun Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorHo Jin Han-
dc.contributor.affiliatedAuthorHye-Min Kim-
dc.contributor.affiliatedAuthorJoonsung Hwang-
dc.contributor.affiliatedAuthorKyung Ho Lee-
dc.contributor.affiliatedAuthorHyunjoo Cha-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorJin Ok Yang-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.alternativeName김동현-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName한호진-
dc.contributor.alternativeName김혜민-
dc.contributor.alternativeName황준성-
dc.contributor.alternativeName이경호-
dc.contributor.alternativeName차현주-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName양진옥-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName송은주-
dc.contributor.alternativeName김진영-
dc.contributor.alternativeName허양훈-
dc.contributor.alternativeName권용태-
dc.contributor.alternativeName성낙균-
dc.contributor.alternativeName김보연-
dc.identifier.bibliographicCitationCell Death & Disease, vol. 10, no. 8, pp. 570-570-
dc.identifier.doi10.1038/s41419-019-1778-8-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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