Open Access@KRIBBOchang Branch InstituteDivision of National Bio-InfrastructureBio-Resource Central Bank1. Journal Articles
Identification of potential inflammatory inhibitors from Aster tataricus
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | X D Su | - |
| dc.contributor.author | Hyun Jae Jang | - |
| dc.contributor.author | H X Li | - |
| dc.contributor.author | Y H Kim | - |
| dc.contributor.author | S Y Yang | - |
| dc.date.accessioned | 2019-10-28T16:30:27Z | - |
| dc.date.available | 2019-10-28T16:30:27Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.issn | 0045-2068 | - |
| dc.identifier.uri | 10.1016/j.bioorg.2019.103208 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18949 | - |
| dc.description.abstract | Aster tataricus L.f. is a traditional Eastern Asian herbal medicine used for the relief of cough-related illnesses. In this study, 32 known compounds and two novel monoterpene glycosides were isolated from the roots of A. tataricus. With the aid of reported data, elucidation of the root-extract components was carried out using a multitude of spectroscopic techniques. All isolates were investigated for their ability to inhibit nitric oxide (NO) secretion in lipopolysaccharide-activated RAW264.7 cells. Compound 7 remarkably suppressed NO production with an IC50 value of 8.5？μM. In addition, compound 7 exhibited significant inhibitory activity against the production of inflammatory cytokines (prostaglandin E2, interleukin-6, and interleukin-1 beta) and the expression of inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) via inhibition of nuclear factor-kappa B activation. Moreover, compound 7 effectively prevented the downstream activation of the mitogen-activated protein kinase signaling pathway by inhibiting phosphorylation of c-Jun N-terminal kinases, extracellular signal-regulated kinases, and p38. These results outline compound 7 as a potential inhibitor for the broad treatment of inflammatory diseases, such as atopic dermatitis, asthma, and various allergies. | - |
| dc.publisher | Elsevier | - |
| dc.title | Identification of potential inflammatory inhibitors from Aster tataricus | - |
| dc.title.alternative | Identification of potential inflammatory inhibitors from Aster tataricus | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic Chemistry | - |
| dc.citation.number | 0 | - |
| dc.citation.endPage | 103208 | - |
| dc.citation.startPage | 103208 | - |
| dc.citation.volume | 92 | - |
| dc.contributor.affiliatedAuthor | Hyun Jae Jang | - |
| dc.contributor.alternativeName | Su | - |
| dc.contributor.alternativeName | 장현재 | - |
| dc.contributor.alternativeName | Li | - |
| dc.contributor.alternativeName | 김영호 | - |
| dc.contributor.alternativeName | 양세영 | - |
| dc.identifier.bibliographicCitation | Bioorganic Chemistry, vol. 92, pp. 103208-103208 | - |
| dc.identifier.doi | 10.1016/j.bioorg.2019.103208 | - |
| dc.subject.keyword | Aster tataricus | - |
| dc.subject.keyword | Asteraceae | - |
| dc.subject.keyword | Inflammatory | - |
| dc.subject.keyword | NF-κB | - |
| dc.subject.keyword | MAPKs | - |
| dc.subject.local | Aster tataricus | - |
| dc.subject.local | asteraceae | - |
| dc.subject.local | Asteraceae | - |
| dc.subject.local | inflammatory | - |
| dc.subject.local | Inflammatory | - |
| dc.subject.local | Nuclear factor-kappa B | - |
| dc.subject.local | nuclear factor κB | - |
| dc.subject.local | Nf-κb | - |
| dc.subject.local | NF-kB | - |
| dc.subject.local | nuclear factor kappa B | - |
| dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
| dc.subject.local | NF-kappaB | - |
| dc.subject.local | Nuclear factor-κb | - |
| dc.subject.local | NF-κ B | - |
| dc.subject.local | NF-κB | - |
| dc.subject.local | NF-kappa B | - |
| dc.subject.local | Nuclear factor κB (NF-κB) | - |
| dc.subject.local | Nuclear factor κB | - |
| dc.subject.local | NFκB | - |
| dc.subject.local | Nf-κB | - |
| dc.subject.local | Nuclear factor-κB | - |
| dc.subject.local | nuclear factorκB | - |
| dc.subject.local | Nuclear factor (NF)-κB | - |
| dc.subject.local | Nuclear factor kappa B | - |
| dc.subject.local | nuclear factor-κB | - |
| dc.subject.local | NF-ΚB | - |
| dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappaB | - |
| dc.subject.local | nuclear factor-kappaB | - |
| dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
| dc.subject.local | NFkappaB | - |
| dc.subject.local | Nuclear factor kappaB | - |
| dc.subject.local | MAPK | - |
| dc.subject.local | MAPKs | - |
| dc.description.journalClass | Y | - |
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