Hepatoprotective activity of a taurine-rich water soluble extract from Octopus vulgaris meat

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Title
Hepatoprotective activity of a taurine-rich water soluble extract from Octopus vulgaris meat
Author(s)
W W Lee; E J Han; E Park; E J Shin; H J Han; Kyungsook Jung; S J Heo; E A Kim; K N Kim; I S Kwak; M J Kim; G Ahn
Bibliographic Citation
Advances in Experimental Medicine and Biology, vol. 1155, pp. 691-703
Publication Year
2019
Abstract
In this study, we investigated the hepatoprotective activity of the water extract derived from Octopus vulgaris meat (OM). First of all, a water extract prepared from OM (OMW) showed the high extraction yield (48.22%) and the highest taurine content (39.84%) in free amino acids. OMW exhibited the high value of reducing power, ABTS and hydrogen peroxide radical scavenging activities in dose-dependent manner. The taurine-rich OMW also led to the reduced intracellular reactive oxygen species (ROS) generation with the increased cell survival in H2O2-treated Chang liver cells. In addition, OMW decreased the apoptotic phenomenon, including the formations of apoptotic bodies and sub-G1 DNA contents by regulating the protein expressions of apoptosis-related molecules such as Bcl-2 and Bax. From these results, this study indicated the taurine-rich OMW protected hepatocytes against oxidative stress. These findings suggest that OWM may be a novel potential antioxidant resource.
Keyword
TaurineOctopus vulgarisHepatoprotective activityApoptosis
ISSN
0065-2598
Publisher
Springer
DOI
http://dx.doi.org/10.1007/978-981-13-8023-5_60
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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