A human pathogenic bacterium Shigella proliferates in plants through adoption of type III effectors for shigellosis

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dc.contributor.authorSung Hee Jo-
dc.contributor.authorJiyoung Lee-
dc.contributor.authorE Park-
dc.contributor.authorD W Kim-
dc.contributor.authorDae-Hee Lee-
dc.contributor.authorChoong-Min Ryu-
dc.contributor.authorD Choi-
dc.contributor.authorJeong Mee Park-
dc.date.accessioned2020-02-07T16:30:17Z-
dc.date.available2020-02-07T16:30:17Z-
dc.date.issued2019-
dc.identifier.issn01407791-
dc.identifier.uri10.1111/pce.13603ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19088-
dc.description.abstractShigella, which infects primates, can be transmitted via fresh vegetables; however, its molecular interactions with plants have not been elucidated. Here, we show that four Shigella strains, Shigella boydii, Shigella sonnei, Shigella flexneri 2a, and S. flexneri 5a, proliferate at different levels in Arabidopsis thaliana. Microscopic studies revealed that these bacteria were present inside leaves and damaged plant cells. Green fluorescent protein (GFP)-tagged S. boydii and S. flexneri 5a colonized leaves only, whereas S. flexneri 2a colonized both leaves and roots. Using Shigella mutants lacking type III secretion systems (T3SSs), we found that T3SSs that regulate the pathogenesis of shigellosis in humans also play a central role in bacterial proliferation in Arabidopsis. Strikingly, the immunosuppressive activity of two T3S effectors, OspF and OspG, was required for proliferation of Shigella in Arabidopsis. Of note, delivery of OspF or OspG effectors inside plant cells upon Shigella inoculation was confirmed using a split GFP system. These findings demonstrate that the human pathogen Shigella can proliferate in plants by adapting immunosuppressive machinery used in the original host human.-
dc.publisherWiley-
dc.titleA human pathogenic bacterium Shigella proliferates in plants through adoption of type III effectors for shigellosis-
dc.title.alternativeA human pathogenic bacterium Shigella proliferates in plants through adoption of type III effectors for shigellosis-
dc.typeArticle-
dc.citation.titlePlant Cell and Environment-
dc.citation.number11-
dc.citation.endPage2978-
dc.citation.startPage2962-
dc.citation.volume42-
dc.contributor.affiliatedAuthorSung Hee Jo-
dc.contributor.affiliatedAuthorJiyoung Lee-
dc.contributor.affiliatedAuthorDae-Hee Lee-
dc.contributor.affiliatedAuthorChoong-Min Ryu-
dc.contributor.affiliatedAuthorJeong Mee Park-
dc.contributor.alternativeName조성희-
dc.contributor.alternativeName이지영-
dc.contributor.alternativeName박은숙-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeName이대희-
dc.contributor.alternativeName류충민-
dc.contributor.alternativeName최도일-
dc.contributor.alternativeName박정미-
dc.identifier.bibliographicCitationPlant Cell and Environment, vol. 42, no. 11, pp. 2962-2978-
dc.identifier.doi10.1111/pce.13603-
dc.subject.keywordArabidopsis plants-
dc.subject.keywordPAMP-triggered immunity-
dc.subject.keywordShigella spp.-
dc.subject.keywordT3S effectors-
dc.subject.keywordalternative host-
dc.subject.keywordenteropathogenic bacteria-
dc.subject.keywordproliferation-
dc.subject.keywordsplit GFP-
dc.subject.keywordtrans-kingdom pathogenesis-
dc.subject.keywordtype III secretion system (T3SS)-
dc.subject.localArabidopsis plants-
dc.subject.localPAMP-triggered immunity-
dc.subject.localShigella spp.-
dc.subject.localT3S effectors-
dc.subject.localAlternative host-
dc.subject.localalternative host-
dc.subject.localEnteropathogenic bacteria-
dc.subject.localenteropathogenic bacteria-
dc.subject.localProliferation-
dc.subject.localproliferation-
dc.subject.localSplit GFP-
dc.subject.localsplit GFP-
dc.subject.localtrans-kingdom pathogenesis-
dc.subject.localType III secretion system-
dc.subject.localtype III secretion system-
dc.subject.localtype III secretion system (T3SS)-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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