Isolation and characterization of the insect growth regulatory substances from actinomycetes

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Title
Isolation and characterization of the insect growth regulatory substances from actinomycetes
Author(s)
J H Kim; J Y Choi; D H Park; Dong Jin Park; M G Park; So Young Kim; Yoon Jung Ju; J Y Kim; M Wang; Chang-Jin Kim; Y H Je
Bibliographic Citation
Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, vol. 228, pp. 108651-108651
Publication Year
2020
Abstract
Insect growth regulators (IGRs) are attractive alternatives to chemical insecticides. Since it has been reported that secondary metabolites from actinomycetes show insecticidal activities against various insect pests, actinomycetes could be a potential source of novel IGR compounds. In the present study, insect juvenile hormone antagonists (JHANs) were identified from actinomycetes and their insect growth regulatory and insecticidal activities were investigated. A total of 363 actinomycetes were screened for their insect growth regulatory and insecticidal activities against Aedes albopictus and Plutella xylostella. Among them, Streptomyces sp. AN120537 showed the highest JHAN and insecticidal activities. Five antimycins were isolated as active compounds by assay-guided fractionation and showed high JHAN activities. These antimycins also exhibited significant insecticidal activities against A. albopictus, P. xylostella, F. occidentalis, and T. urticae. Moreover, dead larvae treated with these antimycins displayed morphological deformities that are similar to those of JH-based IGR-treated insects. This is the first report demonstrating that the insecticidal activities of antimycins resulted from their possible JHAN activity. Based on our results, it is expected that novel JHAN compounds potentially derived from actinomycetes could be efficiently applied as IGR insecticides with a broad insecticidal spectrum.
Keyword
AntimycinsInsecticidal activityJuvenile hormone antagonistSecondary metabolitesStreptomyces
ISSN
0742-8413
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.cbpc.2019.108651
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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