DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hae-Rim Kim | - |
dc.contributor.author | Faiz Ur Rahman | - |
dc.contributor.author | Kwang Soo Kim | - |
dc.contributor.author | Eun-Kyeung Kim | - |
dc.contributor.author | Sang Mi Cho | - |
dc.contributor.author | Kihoon Lee | - |
dc.contributor.author | Ok Sung Moon | - |
dc.contributor.author | Young Won Seo | - |
dc.contributor.author | Won Kee Yoon | - |
dc.contributor.author | Young Suk Won | - |
dc.contributor.author | Hoyoung Kang | - |
dc.contributor.author | Hyoung-Chin Kim | - |
dc.contributor.author | Ki Hoan Nam | - |
dc.date.accessioned | 2020-02-07T16:30:32Z | - |
dc.date.available | 2020-02-07T16:30:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | 10.7150/ijms.39068 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/19140 | - |
dc.description.abstract | E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 in vivo. We examined phenotypic abnormalities, by deletion of the E2f3 gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The E2f3+/ - mouse embryo developed normally without fatal disorder. However, they exhibited reduced body weight, growth retardation, skeletal imperfection, and poor grip strength ability. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth. | - |
dc.publisher | Ivyspring Int Publ | - |
dc.title | Critical roles of E2f3 in Growth and musculo-skeletal phenotype in mice | - |
dc.title.alternative | Critical roles of E2f3 in Growth and musculo-skeletal phenotype in mice | - |
dc.type | Article | - |
dc.citation.title | International Journal of Medical Sciences | - |
dc.citation.number | 12 | - |
dc.citation.endPage | 1563 | - |
dc.citation.startPage | 1557 | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Hae-Rim Kim | - |
dc.contributor.affiliatedAuthor | Kwang Soo Kim | - |
dc.contributor.affiliatedAuthor | Eun-Kyeung Kim | - |
dc.contributor.affiliatedAuthor | Sang Mi Cho | - |
dc.contributor.affiliatedAuthor | Kihoon Lee | - |
dc.contributor.affiliatedAuthor | Ok Sung Moon | - |
dc.contributor.affiliatedAuthor | Young Won Seo | - |
dc.contributor.affiliatedAuthor | Won Kee Yoon | - |
dc.contributor.affiliatedAuthor | Young Suk Won | - |
dc.contributor.affiliatedAuthor | Hoyoung Kang | - |
dc.contributor.affiliatedAuthor | Hyoung-Chin Kim | - |
dc.contributor.affiliatedAuthor | Ki Hoan Nam | - |
dc.contributor.alternativeName | 김해림 | - |
dc.contributor.alternativeName | Rahman | - |
dc.contributor.alternativeName | 김광수 | - |
dc.contributor.alternativeName | 김은경 | - |
dc.contributor.alternativeName | 조상미 | - |
dc.contributor.alternativeName | 이기훈 | - |
dc.contributor.alternativeName | 문옥성 | - |
dc.contributor.alternativeName | 서영원 | - |
dc.contributor.alternativeName | 윤원기 | - |
dc.contributor.alternativeName | 원영석 | - |
dc.contributor.alternativeName | 강호영 | - |
dc.contributor.alternativeName | 김형진 | - |
dc.contributor.alternativeName | 남기환 | - |
dc.identifier.bibliographicCitation | International Journal of Medical Sciences, vol. 16, no. 12, pp. 1557-1563 | - |
dc.identifier.doi | 10.7150/ijms.39068 | - |
dc.subject.keyword | Development | - |
dc.subject.keyword | E2f3+/- Knockout | - |
dc.subject.keyword | Growth retardation | - |
dc.subject.keyword | Mouse phenotype | - |
dc.subject.keyword | skeletal imperfection | - |
dc.subject.local | development | - |
dc.subject.local | deveoopment | - |
dc.subject.local | Development | - |
dc.subject.local | E2f3+/- Knockout | - |
dc.subject.local | growth retardation | - |
dc.subject.local | Growth retardation | - |
dc.subject.local | Mouse phenotype | - |
dc.subject.local | skeletal imperfection | - |
dc.description.journalClass | Y | - |
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