Extension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling

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dc.contributor.authorS H Lee-
dc.contributor.authorH Y Lee-
dc.contributor.authorM Yu-
dc.contributor.authorEunbyul Yeom-
dc.contributor.authorJ H Lee-
dc.contributor.authorA Yoon-
dc.contributor.authorKyu-Sun Lee-
dc.contributor.authorK J Min-
dc.date.accessioned2020-02-07T16:30:34Z-
dc.date.available2020-02-07T16:30:34Z-
dc.date.issued2019-
dc.identifier.issn1945-4589-
dc.identifier.uri10.18632/aging.102387ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19152-
dc.description.abstractMany studies have indicated that Korean red ginseng (KRG) has anti-inflammatory and anti-oxidative effects, thereby inducing many health benefits in humans. Studies into the longevity effects of KRG are limited and have provided contradictory results, and the molecular mechanism of lifespan extension by KRG is not elucidated yet. Herein, the longevity effect of KRG was investigated in Drosophila melanogaster by feeding KRG extracts, and the molecular mechanism of lifespan extension was elucidated by using longevity-related mutant flies. KRG extended the lifespan of Drosophila when administrated at 10 and 25 μg/mL, and the longevity benefit of KRG was not due to reduced feeding, reproduction, and/or climbing ability in fruit flies, indicating that the longevity benefit of KRG is a direct effect of KRG, not of a secondary artifact. Diet supplementation with KRG increased the lifespan of flies on a full-fed diet but not of those on a restricted diet, and the longevity effect of KRG was diminished by the mutation of dSir2, a deacetylase known to mediate the benefits of dietary restriction. Similarly, the longevity effect of KRG was mediated by the reduction of insulin/IGF-1 signaling. In conclusion, KRG extends the lifespan of Drosophila through Sir2 and insulin/IGF-1 signaling and has potential as an anti-aging dietary-restriction mimetic and prolongevity supplement.-
dc.publisherImpact Journals Llc-
dc.titleExtension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling-
dc.title.alternativeExtension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling-
dc.typeArticle-
dc.citation.titleAging-Us-
dc.citation.number21-
dc.citation.endPage9387-
dc.citation.startPage9369-
dc.citation.volume11-
dc.contributor.affiliatedAuthorEunbyul Yeom-
dc.contributor.affiliatedAuthorKyu-Sun Lee-
dc.contributor.alternativeName이신해-
dc.contributor.alternativeName이혜연-
dc.contributor.alternativeName유미라-
dc.contributor.alternativeName염은별-
dc.contributor.alternativeName이지현-
dc.contributor.alternativeName윤아-
dc.contributor.alternativeName이규선-
dc.contributor.alternativeName민경진-
dc.identifier.bibliographicCitationAging-Us, vol. 11, no. 21, pp. 9369-9387-
dc.identifier.doi10.18632/aging.102387-
dc.subject.keywordDrosophila melanogaster-
dc.subject.keywordSir2-
dc.subject.keywordinsulin/IGF-1 signaling-
dc.subject.keywordkorean red ginseng-
dc.subject.keywordlifespan-
dc.subject.localdrosophila melanogaster-
dc.subject.localDrosophila melanogaster-
dc.subject.localSir2-
dc.subject.localinsulin/IGF-1 signaling-
dc.subject.localKorean red ginseng-
dc.subject.localkorean red ginseng-
dc.subject.locallifespan-
dc.subject.localLifespan-
dc.description.journalClassY-
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