Resorcinosides A and B, glycosylated alkylresorcinols from a marine-derived strain of the fungus Penicillium janthinellum

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Title
Resorcinosides A and B, glycosylated alkylresorcinols from a marine-derived strain of the fungus Penicillium janthinellum
Author(s)
B K Choi; T H T; S Hwang; D C Oh; Jong Soon Kang; H S Lee; T D N Ngo; T T V Tran; H J Shin
Bibliographic Citation
Journal of Natural Products, vol. 82, no. 11, pp. 3186-3190
Publication Year
2019
Abstract
Two new glycosylated alkylresorcinols, resorcinosides A (1) and B (2), were isolated from a strain of the fungus Penicillium janthinellum derived from a marine sediment sample collected from Cu Lao Cham Island, Vietnam. The structures of 1 and 2 were established by interpretation of 1D and 2D NMR and high-resolution ESIMS data, and their absolute configurations were confirmed by the coupling constant of the anomeric proton, acid hydrolysis, subsequent HPLC analysis, Mosher's method, and quantum-mechanics-based computational analysis of NMR chemical shifts. The structure elucidation indicated that 1 and 2 are new alkylresorcinols with d-glucose, and 2 has an α-pyrone moiety attached to the aromatic ring. Compound 1 exhibited cytotoxic activity against the NUGC-3 cancer cell line with a GI50 value of 9.3 μM.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.9b00776
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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