The roles of hypoxia-inducible factors and non-coding RNAs in gastrointestinal cancer

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Title
The roles of hypoxia-inducible factors and non-coding RNAs in gastrointestinal cancer
Author(s)
Hyun Soo ChoTae Su Han; K Hur; Hyun Seung Ban
Bibliographic Citation
Genes, vol. 10, no. 12, pp. 1008-1008
Publication Year
2019
Abstract
Hypoxia-inducible factors (HIFs) are transcription factors that play central roles in cellular responses against hypoxia. In most cancers, HIFs are closely associated with tumorigenesis by regulating cell survival, angiogenesis, metastasis, and adaptation to the hypoxic tumor microenvironment. Recently, non-coding RNAs (ncRNAs) have been reported to play critical roles in the hypoxic response in various cancers. Here, we review the roles of hypoxia-response ncRNAs in gastrointestinal cancer, with a particular focus on microRNAs and long ncRNAs, and discuss the functional relationships and regulatory mechanisms between HIFs and ncRNAs.
Keyword
gastrointestinal cancerhypoxiahypoxia-inducible factormicroRNAnon-coding RNA
ISSN
2073-4425
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/genes10121008
Type
Article
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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