Development of systems for the production of plant-derived biopharmaceuticals

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Title
Development of systems for the production of plant-derived biopharmaceuticals
Author(s)
Ki-Beom Moon; Ji-Sun Park; Y I Park; In Ja SongHyo Jun LeeHye Sun ChoJae Heung JeonHyun Soon Kim
Bibliographic Citation
Plants-Basel, vol. 9, pp. 30-30
Publication Year
2020
Abstract
Over the last several decades, plants have been developed as a platform for the production of useful recombinant proteins due to a number of advantages, including rapid production and scalability, the ability to produce unique glycoforms, and the intrinsic safety of food crops. The expression methods used to produce target proteins are divided into stable and transient systems depending on applications that use whole plants or minimally processed forms. In the early stages of research, stable expression systems were mostly used; however, in recent years, transient expression systems have been preferred. The production of the plant itself, which produces recombinant proteins, is currently divided into two major approaches, open-field cultivation and closed-indoor systems. The latter encompasses such regimes as greenhouses, vertical farming units, cell bioreactors, and hydroponic systems. Various aspects of each system will be discussed in this review, which focuses mainly on practical examples and commercially feasible approaches.
Keyword
expression systemmolecular farmingplant-derived proteinproduction systemrecombinant protein
ISSN
2223-7747
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/plants9010030
Type
Article
Appears in Collections:
National Research Safety Headquarter > 1. Journal Articles
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