Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model

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Title
Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model
Author(s)
Kang Jin JeongPhilyong KangHwal Yong LeeHee Chang SonSung Hyun ParkWon Seok ChoiBon Sang KooChang Yeop JeonSeung Ho BaekYou Jung An; H K Kim; S S Kim; J K Park; I H Bae; D S Park; J W Shim; J U Kim; N Y Kim; Sun-Uk KimKyung Seob Lim; M H Jeong
Bibliographic Citation
Journal of Biomedical and Translational Research, vol. 20, no. 4, pp. 91-98
Publication Year
2019
Abstract
This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histopathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2 in the CND group vs. 3.3 ± 0.34 mm2 in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2 in the CND group vs. 2.0 ± 0.33 mm2 in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.
Keyword
CholesterolBalloon angioplastyCoronary stentsPercutaneous coronary interventionRestenosis
ISSN
2508-1357
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.12729/jbtr.2019.20.4.091
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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