Ischemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor B

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dc.contributor.authorNa Geum Lee-
dc.contributor.authorI C Jeung-
dc.contributor.authorS C Heo-
dc.contributor.authorJinhoi Song-
dc.contributor.authorWooil Kim-
dc.contributor.authorByungtae Hwang-
dc.contributor.authorMin-Gi Kwon-
dc.contributor.authorYeon-Gu Kim-
dc.contributor.authorJangwook Lee-
dc.contributor.authorJong Gil Park-
dc.contributor.authorMin Gyeong Shin-
dc.contributor.authorYoung Lai Cho-
dc.contributor.authorMi Young Son-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorSang Hyun Lee-
dc.contributor.authorJ H Kim-
dc.contributor.authorJeong Ki Min-
dc.date.accessioned2020-02-07T16:31:01Z-
dc.date.available2020-02-07T16:31:01Z-
dc.date.issued2020-
dc.identifier.issn0892-6638-
dc.identifier.uri10.1096/fj.201900866RRko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19273-
dc.description.abstractEndothelial progenitor cells (EPCs) promote neovascularization and tissue repair by migrating to vascular injury sites; therefore, factors that enhance EPC homing to damaged tissues are of interest. Here, we provide evidence of the prominent role of the Netrin-4 (NTN4)-Unc-5 Netrin receptor B (UNC5B) axis in EPC-specific promotion of ischemic neovascularization. Our results showed that NTN4 promoted the proliferation, chemotactic migration, and paracrine effects of small EPCs (SEPCs) and significantly increased the incorporation of large EPCs (LEPCs) into tubule networks. Additionally, NTN4 prominently augmented neovascularization in mice with hindlimb ischemia by increasing the homing of exogenously transplanted EPCs to the ischemic limb and incorporating EPCs into vessels. Moreover, silencing of UNC5B, an NTN4 receptor, abrogated the NTN4-induced cellular activities of SEPCs in vitro and blood-flow recovery and neovascularization in vivo in ischemic muscle by reducing EPC homing and incorporation. These findings suggest NTN4 as an EPC-based therapy for treating angiogenesis-dependent diseases.-
dc.publisherWiley-
dc.titleIschemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor B-
dc.title.alternativeIschemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor B-
dc.typeArticle-
dc.citation.titleFASEB Journal-
dc.citation.number1-
dc.citation.endPage1246-
dc.citation.startPage1231-
dc.citation.volume34-
dc.contributor.affiliatedAuthorNa Geum Lee-
dc.contributor.affiliatedAuthorJinhoi Song-
dc.contributor.affiliatedAuthorWooil Kim-
dc.contributor.affiliatedAuthorByungtae Hwang-
dc.contributor.affiliatedAuthorMin-Gi Kwon-
dc.contributor.affiliatedAuthorYeon-Gu Kim-
dc.contributor.affiliatedAuthorJangwook Lee-
dc.contributor.affiliatedAuthorJong Gil Park-
dc.contributor.affiliatedAuthorMin Gyeong Shin-
dc.contributor.affiliatedAuthorYoung Lai Cho-
dc.contributor.affiliatedAuthorMi Young Son-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorSang Hyun Lee-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.alternativeName이나금-
dc.contributor.alternativeName정인철-
dc.contributor.alternativeName허순철-
dc.contributor.alternativeName송진회-
dc.contributor.alternativeName김우일-
dc.contributor.alternativeName황병태-
dc.contributor.alternativeName권민기-
dc.contributor.alternativeName김연구-
dc.contributor.alternativeName이장욱-
dc.contributor.alternativeName박종길-
dc.contributor.alternativeName신민경-
dc.contributor.alternativeName조영래-
dc.contributor.alternativeName손미영-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName이상현-
dc.contributor.alternativeName김재호-
dc.contributor.alternativeName민정기-
dc.identifier.bibliographicCitationFASEB Journal, vol. 34, no. 1, pp. 1231-1246-
dc.identifier.doi10.1096/fj.201900866RR-
dc.subject.keywordEPCbased therapy-
dc.subject.keywordNetrin4-
dc.subject.keywordangiogenesisdependent diseases-
dc.subject.keywordendothelial progenitor cells-
dc.subject.keywordneovascularization-
dc.subject.localEPCbased therapy-
dc.subject.localNetrin4-
dc.subject.localangiogenesisdependent diseases-
dc.subject.localendothelial progenitor cells-
dc.subject.localEndothelial progenitor cells-
dc.subject.localendothelial progenitor cell-
dc.subject.localneovascularization-
dc.subject.localNeovascularization-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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