DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang Mi Han | - |
dc.contributor.author | Jun-Pil Jang | - |
dc.contributor.author | Jae-Hyuk Jang | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.contributor.author | H J Jung | - |
dc.date.accessioned | 2020-02-07T16:31:04Z | - |
dc.date.available | 2020-02-07T16:31:04Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | 10.3892/or.2019.7446 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/19288 | - |
dc.description.abstract | While exploring new angiogenesis inhibitors from microbial metabolites, we recently isolated ahpatinins C, E, and G from a soil-derived Streptomyces sp. 15JA150. Ahpatinins C, E and G are known to have pepsin and renin inhibitory activities; however, their antiangiogenic activities and underlying molecular mechanisms have not been fully elucidated. In the present study, the antiangiogenic properties of ahpatinins C, E and G were investigated. The results revealed that the natural compounds significantly inhibited the vascular endothelial growth factor (VEGF)-induced proliferation, invasion, adhesion, and tube formation of human umbilical vein endothelial cells (HUVECs) without exhibiting any cytotoxicity. It was also revealed that ahpatinin E effectively suppressed the neovascularization of the chorioallantoic membranes in growing chick embryos. Notably, ahpatinins C, E, and G led to the downregulation of VEGF-induced activation of VEGF receptor 2 (VEGFR2) and its downstream signaling mediators, including AKT, ERK1/2, JNK, p38, and NF-κB, in HUVECs. Moreover, they reduced the expression of matrix metalloproteinase (MMP)-2 and MMP-9 in the HUVECs following stimulation with VEGF. Furthermore, ahpatinins C, E, and G reduced the tumor cell?induced invasion and tube forming abilities of HUVECs, as well as the expression of VEGF, by suppressing hypoxia-inducible factor-1α (HIF-1α) activity in U87MG glioblastoma cells. Collectively, the present findings indicated that ahpatinins C, E, and G may be used in anticancer therapy by targeting tumor angiogenesis through the inhibition of both VEGFR2 and HIF-1α pathways. | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | Antiangiogenic potentials of ahpatinins obtained from a Streptomyces species | - |
dc.title.alternative | Antiangiogenic potentials of ahpatinins obtained from a Streptomyces species | - |
dc.type | Article | - |
dc.citation.title | Oncology Reports | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 634 | - |
dc.citation.startPage | 625 | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | Jun-Pil Jang | - |
dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 한장미 | - |
dc.contributor.alternativeName | 장준필 | - |
dc.contributor.alternativeName | 장재혁 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.contributor.alternativeName | 정혜진 | - |
dc.identifier.bibliographicCitation | Oncology Reports, vol. 43, no. 2, pp. 625-634 | - |
dc.identifier.doi | 10.3892/or.2019.7446 | - |
dc.subject.keyword | Ahpatinins | - |
dc.subject.keyword | HIF-1α | - |
dc.subject.keyword | Streptomyces sp | - |
dc.subject.keyword | Tumor angiogenesis | - |
dc.subject.keyword | VEGFR2 | - |
dc.subject.local | Ahpatinins | - |
dc.subject.local | Hif1α | - |
dc.subject.local | HIF-1α | - |
dc.subject.local | HIF1α | - |
dc.subject.local | Streptomyces sp | - |
dc.subject.local | Streptomyces sp. | - |
dc.subject.local | streptomyces sp. | - |
dc.subject.local | tumor angiogenesis | - |
dc.subject.local | Tumor angiogenesis | - |
dc.subject.local | VEGFR2 | - |
dc.description.journalClass | Y | - |
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