Antiangiogenic potentials of ahpatinins obtained from a Streptomyces species

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dc.contributor.authorJang Mi Han-
dc.contributor.authorJun-Pil Jang-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorH J Jung-
dc.date.accessioned2020-02-07T16:31:04Z-
dc.date.available2020-02-07T16:31:04Z-
dc.date.issued2020-
dc.identifier.issn1021-335X-
dc.identifier.uri10.3892/or.2019.7446ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19288-
dc.description.abstractWhile exploring new angiogenesis inhibitors from microbial metabolites, we recently isolated ahpatinins C, E, and G from a soil-derived Streptomyces sp. 15JA150. Ahpatinins C, E and G are known to have pepsin and renin inhibitory activities; however, their antiangiogenic activities and underlying molecular mechanisms have not been fully elucidated. In the present study, the antiangiogenic properties of ahpatinins C, E and G were investigated. The results revealed that the natural compounds significantly inhibited the vascular endothelial growth factor (VEGF)-induced proliferation, invasion, adhesion, and tube formation of human umbilical vein endothelial cells (HUVECs) without exhibiting any cytotoxicity. It was also revealed that ahpatinin E effectively suppressed the neovascularization of the chorioallantoic membranes in growing chick embryos. Notably, ahpatinins C, E, and G led to the downregulation of VEGF-induced activation of VEGF receptor 2 (VEGFR2) and its downstream signaling mediators, including AKT, ERK1/2, JNK, p38, and NF-κB, in HUVECs. Moreover, they reduced the expression of matrix metalloproteinase (MMP)-2 and MMP-9 in the HUVECs following stimulation with VEGF. Furthermore, ahpatinins C, E, and G reduced the tumor cell?induced invasion and tube forming abilities of HUVECs, as well as the expression of VEGF, by suppressing hypoxia-inducible factor-1α (HIF-1α) activity in U87MG glioblastoma cells. Collectively, the present findings indicated that ahpatinins C, E, and G may be used in anticancer therapy by targeting tumor angiogenesis through the inhibition of both VEGFR2 and HIF-1α pathways.-
dc.publisherSpandidos Publ Ltd-
dc.titleAntiangiogenic potentials of ahpatinins obtained from a Streptomyces species-
dc.title.alternativeAntiangiogenic potentials of ahpatinins obtained from a Streptomyces species-
dc.typeArticle-
dc.citation.titleOncology Reports-
dc.citation.number2-
dc.citation.endPage634-
dc.citation.startPage625-
dc.citation.volume43-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName한장미-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName정혜진-
dc.identifier.bibliographicCitationOncology Reports, vol. 43, no. 2, pp. 625-634-
dc.identifier.doi10.3892/or.2019.7446-
dc.subject.keywordAhpatinins-
dc.subject.keywordHIF-1α-
dc.subject.keywordStreptomyces sp-
dc.subject.keywordTumor angiogenesis-
dc.subject.keywordVEGFR2-
dc.subject.localAhpatinins-
dc.subject.localHif1α-
dc.subject.localHIF-1α-
dc.subject.localHIF1α-
dc.subject.localStreptomyces sp-
dc.subject.localStreptomyces sp.-
dc.subject.localstreptomyces sp.-
dc.subject.localtumor angiogenesis-
dc.subject.localTumor angiogenesis-
dc.subject.localVEGFR2-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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