Poly-L-lactide polymer-based triple drug-eluting stent with abciximab, alpha-lipoic acid and sirolimus in porcine coronary restenosis model

Cited 0 time in scopus
Metadata Downloads
Title
Poly-L-lactide polymer-based triple drug-eluting stent with abciximab, alpha-lipoic acid and sirolimus in porcine coronary restenosis model
Author(s)
J K Park; S S Kim; H K Kim; J W Nah; H B Kim; I H Bae; D S Park; J W Shim; M Y Lee; J S Kim; Bon Sang KooKang Jin Jeong; Yeung Bae Jin; Sun-Uk Kim; Sang-Rae Lee; J Y Na; D S Sim; Y J Hong; Kyungseob Lim; M H Jeong
Bibliographic Citation
Macromolecular Research, vol. 28, no. 1, pp. 9-14
Publication Year
2020
Abstract
This study evaluated the effect of a novel triple drug-eluting stent containing antithrombotic abciximab, antioxidative alpha-lipoic acid (ALA), and antiproliferative sirolimus in a porcine model. The coronary arteries of pigs were randomized into three groups: triple drug-eluting stent (TES; n=10), sirolimus-eluting stent (SES; n=10), and bare metal stent (BMS; n=10). At 28 days after stent implantation, a histopathologic analysis was performed. There were no significant differences in the injury score. There were significant differences in the neointimal area (2.3±0.6 mm2 in TES vs. 2.5±0.88 mm2 in SES vs. 3.3±0.58 mm2 in BMS, p<0.0001), percent area of stenosis (37.1±9.26% in TES vs. 46.1±15.9% in SES vs. 66.2±10.12% in BMS, p<0.0001), inflammation score (1.0 [range, 0.0-1.0] in TES vs. 1.5 [range, 1.0-2.0] in SES vs. 1.0 [range, 1.0-2.0] in BMS, p<0.05), and fibrin score (2.0 [range, 1.0-2.0] in TES vs. 2.0 [range, 1.0-2.5] in SES vs. 0.0 [range, 0.0-1.0] in BMS, p<0.0001) among the three groups. The occlusion rates using micro-computed tomography showed similar restenosis rates based on histologic analysis (35.4±8.39% in TES vs. 43.4±10.12% in SES vs. 71.4±4.38% in BMS, p<0.0001). TES demonstrated an inhibitory effect on the smooth muscle cells compared to the other stents. It also suppressed inflammation in the stented lesion compared to SES as evidenced by the inflammation score.
Keyword
drug-eluting stentsneointimal hyperplasiapercutaneous coronary interventionrestenosisinflammationpolymer
ISSN
1598-5032
Publisher
Polymer Soc Korea
DOI
http://dx.doi.org/10.1007/s13233-020-8004-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.