Toll-like receptors in natural killer cells and their application for immunotherapy

Cited 12 time in scopus
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Title
Toll-like receptors in natural killer cells and their application for immunotherapy
Author(s)
Ji Yoon NohSuk Ran YoonTae-Don Kim; In Pyo Choi; Haiyoung Jung
Bibliographic Citation
Journal of Immunology Research, vol. 2020, pp. 2045860-2045860
Publication Year
2020
Abstract
Innate immunity represents the first barrier for host defense against microbial infection. Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses. They recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses by inducing inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules. TLRs are expressed either on the cell surface or within endosomes of innate immune cells. NK cells are one of the innate immune cells and also express TLRs to recognize or respond to PAMPs. TLRs in NK cells induce the innate immune responses against bacterial and viral infections via inducing NK cytotoxicity and cytokine production. In this review, we will discuss the expression and cellular function of TLRs in NK cells and also introduce some therapeutic applications of TLR agonists for NK cell-mediated immunotherapy.
ISSN
2314-8861
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1155/2020/2045860
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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