CRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in Rat 3Y1 fibroblast cells

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dc.contributor.authorY Asami-
dc.contributor.authorSun Ok Kim-
dc.contributor.authorJun-Pil Jang-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorH Osada-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2020-04-24T16:30:05Z-
dc.date.available2020-04-24T16:30:05Z-
dc.date.issued2020-
dc.identifier.issn10177825-
dc.identifier.uri10.4014/jmb.1908.08043ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19321-
dc.description.abstractWe previously identified a new heparinase inhibitor fungal metabolite, named CRM646-A, which showed inhibition of heparinase and telomerase activities in an in vitro enzyme assay and antimetastatic activity in a cell-based assay. In this study, we elucidated the mechanism by which CRM646-A rapidly induced nucleus condensation, plasma membrane disruption and morphological changes by increasing intracellular Ca2+ levels. Furthermore, PD98059, a mitogen-activated protein kinase (MEK) inhibitor, inhibited CRM646-A-induced nucleus condensation through ERK1/2 activation in rat 3Y1 fibroblast cells. We identified CRM646-A as a Ca2+ ionophore-like agent with a distinctly different chemical structure from that of previously reported Ca2+ ionophores. These results indicate that CRM646-A has the potential to be used as a new and effective antimetastatic drug.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleCRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in Rat 3Y1 fibroblast cells-
dc.title.alternativeCRM646-A, a fungal metabolite, induces nucleus condensation by increasing Ca2+ levels in Rat 3Y1 fibroblast cells-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number1-
dc.citation.endPage37-
dc.citation.startPage31-
dc.citation.volume30-
dc.contributor.affiliatedAuthorSun Ok Kim-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeNameAsami-
dc.contributor.alternativeName김선옥-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 30, no. 1, pp. 31-37-
dc.identifier.doi10.4014/jmb.1908.08043-
dc.subject.keywordCa² ionophore-like agent-
dc.subject.keywordCa² signaling-
dc.subject.keywordERK pathway-
dc.subject.keywordNucleus condensation-
dc.subject.keywordplasma membrane-
dc.subject.localCa² ionophore-like agent-
dc.subject.localCa² signaling-
dc.subject.localERK pathway-
dc.subject.localNucleus condensation-
dc.subject.localplasma membrane-
dc.subject.localPlasma membrane-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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