A pilot study on assessment of locomotor behavior using a video tracking system in minipigs

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dc.contributor.authorJincheol Seo-
dc.contributor.authorHyeon-Gu Yeo-
dc.contributor.authorJunghyung Park-
dc.contributor.authorJinyoung Won-
dc.contributor.authorKeonwoo Kim-
dc.contributor.authorYeung Bae Jin-
dc.contributor.authorBon Sang Koo-
dc.contributor.authorKyung Seob Lim-
dc.contributor.authorKang Jin Jeong-
dc.contributor.authorPhilyong Kang-
dc.contributor.authorHwal Yong Lee-
dc.contributor.authorHee Chang Son-
dc.contributor.authorSeung Ho Baek-
dc.contributor.authorChang Yeop Jeon-
dc.contributor.authorBong-Seok Song-
dc.contributor.authorJae Won Huh-
dc.contributor.authorD S Lee-
dc.contributor.authorSang-Rae Lee-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorYoungjeon Lee-
dc.date.accessioned2020-04-24T16:30:07Z-
dc.date.available2020-04-24T16:30:07Z-
dc.date.issued2020-
dc.identifier.issn1341-1357-
dc.identifier.uri10.1538/expanim.19-0065ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19328-
dc.description.abstractPigs are often selected for large animal models including for neuroscience and behavioral research, because their anatomy and biochemistry are similar to those of humans. However, behavioral assessments, in combination with objective long-term monitoring, is difficult. In this study, we introduced an automated video tracking system which was previously used in rodent studies, for use with pig models. Locomotor behaviors (total distance, number of zone transitions, and velocity) were evaluated and their changes were validated by different 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration methods and dosing regimens. Three minipigs (23-29 kg) received subcutaneous or intravenous MPTP, either 1 or 3 times per week. Immediately after MPTP injection, the minipigs remained in a corner and exhibited reduced trajectory. In addition, the total distance travelled, number of zone transitions, and velocity were greatly reduced at every MPTP administration in all the minipigs, accompanying to increased resting time. However, the MPTP-induced symptoms were reversed when MPTP administration was terminated. In conclusion, this automated video-tracking system was able to monitor long-term locomotor activity and differentiate detailed alterations in large animals. It has the advantages of being easy to use, higher resolution, less effort, and more delicate tracking. Additionally, as our method can be applied to the animals' home pen, no habituation is needed.-
dc.publisherInt Press Editing Centre Inc-
dc.titleA pilot study on assessment of locomotor behavior using a video tracking system in minipigs-
dc.title.alternativeA pilot study on assessment of locomotor behavior using a video tracking system in minipigs-
dc.typeArticle-
dc.citation.titleExperimental Animals-
dc.citation.number1-
dc.citation.endPage69-
dc.citation.startPage62-
dc.citation.volume69-
dc.contributor.affiliatedAuthorJincheol Seo-
dc.contributor.affiliatedAuthorHyeon-Gu Yeo-
dc.contributor.affiliatedAuthorJunghyung Park-
dc.contributor.affiliatedAuthorJinyoung Won-
dc.contributor.affiliatedAuthorKeonwoo Kim-
dc.contributor.affiliatedAuthorYeung Bae Jin-
dc.contributor.affiliatedAuthorBon Sang Koo-
dc.contributor.affiliatedAuthorKyung Seob Lim-
dc.contributor.affiliatedAuthorKang Jin Jeong-
dc.contributor.affiliatedAuthorPhilyong Kang-
dc.contributor.affiliatedAuthorHwal Yong Lee-
dc.contributor.affiliatedAuthorHee Chang Son-
dc.contributor.affiliatedAuthorSeung Ho Baek-
dc.contributor.affiliatedAuthorChang Yeop Jeon-
dc.contributor.affiliatedAuthorBong-Seok Song-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorSang-Rae Lee-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorYoungjeon Lee-
dc.contributor.alternativeName서진철-
dc.contributor.alternativeName여현구-
dc.contributor.alternativeName박정형-
dc.contributor.alternativeName원진영-
dc.contributor.alternativeName김건우-
dc.contributor.alternativeName진영배-
dc.contributor.alternativeName구본상-
dc.contributor.alternativeName임경섭-
dc.contributor.alternativeName정강진-
dc.contributor.alternativeName강필용-
dc.contributor.alternativeName이활용-
dc.contributor.alternativeName손희창-
dc.contributor.alternativeName백승호-
dc.contributor.alternativeName전창엽-
dc.contributor.alternativeName송봉석-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName이동석-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName이영전-
dc.identifier.bibliographicCitationExperimental Animals, vol. 69, no. 1, pp. 62-69-
dc.identifier.doi10.1538/expanim.19-0065-
dc.subject.keyword1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-
dc.subject.keywordbehavior-
dc.subject.keywordlocomotor-
dc.subject.keywordminipig-
dc.subject.keywordvideo tracking-
dc.subject.local1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-
dc.subject.localBehavior-
dc.subject.localbehavior-
dc.subject.locallocomotor-
dc.subject.localmini-pig-
dc.subject.localminipig-
dc.subject.localMini-pig-
dc.subject.localMinipig-
dc.subject.localvideo tracking-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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