Regulation of PTP1B activation through disruption of redox-complex formation

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Title
Regulation of PTP1B activation through disruption of redox-complex formation
Author(s)
A D Londhe; A Bergeron; S M Curley; F Zhang; K D Rivera; A Kannan; G Coulis; S H M Rizvi; Seung Jun Kim; D J Pappin; N K Tonks; R J Linhardt; B Boivin
Bibliographic Citation
Nature Chemical Biology, vol. 16, pp. 122-125
Publication Year
2020
Abstract
We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3ζ and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells.
ISSN
1552-4450
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/s41589-019-0433-0
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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