Wnt3a stimulation promotes primary ciliogenesis through beta-catenin phosphorylation-induced reorganization of centriolar satellites

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dc.contributor.authorMi-Lang Kyun-
dc.contributor.authorSun Ok Kim-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorJ A Hwang-
dc.contributor.authorJoonsung Hwang-
dc.contributor.authorNak Kyun Soung-
dc.contributor.authorHyunjoo Cha-
dc.contributor.authorSangku Lee-
dc.contributor.authorY T Kwon-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorKyung Ho Lee-
dc.date.accessioned2020-04-24T16:30:10Z-
dc.date.available2020-04-24T16:30:10Z-
dc.date.issued2020-
dc.identifier.issn2211-1247-
dc.identifier.uri10.1016/j.celrep.2020.01.019ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19337-
dc.description.abstractPrimary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer. The Wnt signaling pathway plays a major role in embryonic development and tissue homeostasis, and defects in Wnt signaling are associated with a variety of human diseases, including cancer. In this study, we provide direct evidence of Wnt3a-induced primary ciliogenesis, which includes a continuous pathway showing that the stimulation of Wnt3a, a canonical Wnt ligand, promotes the generation of β-catenin p-S47 epitope by CK1δ, and these events lead to the reorganization of centriolar satellites resulting in primary ciliogenesis. We have also confirmed the application of our findings in MCF-7/ADR cells, a multidrug-resistant tumor cell model. Thus, our data provide a Wnt3a-induced primary ciliogenesis pathway and may provide a clue on how to overcome multidrug resistance in cancer treatment.-
dc.publisherElsevier-Cell Press-
dc.titleWnt3a stimulation promotes primary ciliogenesis through beta-catenin phosphorylation-induced reorganization of centriolar satellites-
dc.title.alternativeWnt3a stimulation promotes primary ciliogenesis through beta-catenin phosphorylation-induced reorganization of centriolar satellites-
dc.typeArticle-
dc.citation.titleCell Reports-
dc.citation.number0-
dc.citation.endPage1462-
dc.citation.startPage1447-
dc.citation.volume30-
dc.contributor.affiliatedAuthorMi-Lang Kyun-
dc.contributor.affiliatedAuthorSun Ok Kim-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorJoonsung Hwang-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.affiliatedAuthorHyunjoo Cha-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorKyung Ho Lee-
dc.contributor.alternativeName견미랑-
dc.contributor.alternativeName김선옥-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName황정아-
dc.contributor.alternativeName황준성-
dc.contributor.alternativeName성낙균-
dc.contributor.alternativeName차현주-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName권용태-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName이경호-
dc.identifier.bibliographicCitationCell Reports, vol. 30, pp. 1447-1462-
dc.identifier.doi10.1016/j.celrep.2020.01.019-
dc.subject.keywordWnt3a-
dc.subject.keywordcentriolar satellites-
dc.subject.keywordmultidrug-resistant tumor cell-
dc.subject.keywordprimary ciliogenesis-
dc.subject.keywordβ-catenin p-S47-
dc.subject.localWnt3a-
dc.subject.localcentriolar satellites-
dc.subject.localmultidrug-resistant tumor cell-
dc.subject.localprimary ciliogenesis-
dc.subject.localPrimary ciliogenesis-
dc.subject.localβ-catenin p-S47-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Nucleic Acid Therapeutics Research Center > 1. Journal Articles
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