DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mi-Lang Kyun | - |
dc.contributor.author | Sun Ok Kim | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | J A Hwang | - |
dc.contributor.author | Joonsung Hwang | - |
dc.contributor.author | Nak Kyun Soung | - |
dc.contributor.author | Hyunjoo Cha | - |
dc.contributor.author | Sangku Lee | - |
dc.contributor.author | Y T Kwon | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Kyung Ho Lee | - |
dc.date.accessioned | 2020-04-24T16:30:10Z | - |
dc.date.available | 2020-04-24T16:30:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | 10.1016/j.celrep.2020.01.019 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/19337 | - |
dc.description.abstract | Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer. The Wnt signaling pathway plays a major role in embryonic development and tissue homeostasis, and defects in Wnt signaling are associated with a variety of human diseases, including cancer. In this study, we provide direct evidence of Wnt3a-induced primary ciliogenesis, which includes a continuous pathway showing that the stimulation of Wnt3a, a canonical Wnt ligand, promotes the generation of β-catenin p-S47 epitope by CK1δ, and these events lead to the reorganization of centriolar satellites resulting in primary ciliogenesis. We have also confirmed the application of our findings in MCF-7/ADR cells, a multidrug-resistant tumor cell model. Thus, our data provide a Wnt3a-induced primary ciliogenesis pathway and may provide a clue on how to overcome multidrug resistance in cancer treatment. | - |
dc.publisher | Elsevier-Cell Press | - |
dc.title | Wnt3a stimulation promotes primary ciliogenesis through beta-catenin phosphorylation-induced reorganization of centriolar satellites | - |
dc.title.alternative | Wnt3a stimulation promotes primary ciliogenesis through beta-catenin phosphorylation-induced reorganization of centriolar satellites | - |
dc.type | Article | - |
dc.citation.title | Cell Reports | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 1462 | - |
dc.citation.startPage | 1447 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Mi-Lang Kyun | - |
dc.contributor.affiliatedAuthor | Sun Ok Kim | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.affiliatedAuthor | Joonsung Hwang | - |
dc.contributor.affiliatedAuthor | Nak Kyun Soung | - |
dc.contributor.affiliatedAuthor | Hyunjoo Cha | - |
dc.contributor.affiliatedAuthor | Sangku Lee | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Kyung Ho Lee | - |
dc.contributor.alternativeName | 견미랑 | - |
dc.contributor.alternativeName | 김선옥 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.contributor.alternativeName | 황정아 | - |
dc.contributor.alternativeName | 황준성 | - |
dc.contributor.alternativeName | 성낙균 | - |
dc.contributor.alternativeName | 차현주 | - |
dc.contributor.alternativeName | 이상구 | - |
dc.contributor.alternativeName | 권용태 | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 이경호 | - |
dc.identifier.bibliographicCitation | Cell Reports, vol. 30, pp. 1447-1462 | - |
dc.identifier.doi | 10.1016/j.celrep.2020.01.019 | - |
dc.subject.keyword | Wnt3a | - |
dc.subject.keyword | centriolar satellites | - |
dc.subject.keyword | multidrug-resistant tumor cell | - |
dc.subject.keyword | primary ciliogenesis | - |
dc.subject.keyword | β-catenin p-S47 | - |
dc.subject.local | Wnt3a | - |
dc.subject.local | centriolar satellites | - |
dc.subject.local | multidrug-resistant tumor cell | - |
dc.subject.local | primary ciliogenesis | - |
dc.subject.local | Primary ciliogenesis | - |
dc.subject.local | β-catenin p-S47 | - |
dc.description.journalClass | Y | - |
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