Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening

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dc.contributor.authorByeongsan Lee-
dc.contributor.authorSangkeun Son-
dc.contributor.authorJae Kyoung Lee-
dc.contributor.authorMina Jang-
dc.contributor.authorKyung Taek Heo-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorDong Jin Park-
dc.contributor.authorChan Sun Park-
dc.contributor.authorChang-Jin Kim-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorB Y Hwang-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorYoung-Soo Hong-
dc.date.accessioned2020-04-24T16:30:10Z-
dc.date.available2020-04-24T16:30:10Z-
dc.date.issued2020-
dc.identifier.issn00218820-
dc.identifier.uri10.1038/s41429-019-0264-yko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19338-
dc.description.abstractA LC-MS-guided screening led to the isolation of two new streptimidone derivatives (2 and 3) containing a glutarimide ring and two glutarimide ring-opened compounds (4 and 5) along with a known glutarimide-containing polyketide, streptimidone (1) from Streptomyces sp. W3002 strain. Their structures were elucidated by MS and NMR spectroscopic analyses and by comparison with data from the literature. Compound 2 is a non-hydroxylated analog at the C-5 position of streptimidone. The structure of 3 was determined as a streptimidone derivative possessing the α, β-unsaturated ketone moiety at positions C-5 and C-6. Compound 4 had similar chemical shifts and splitting patterns with 3, but the glutarimide ring is opened. Compound 5 closely resembles that of 4 with the only difference being the existence of an additional methoxy group instead of an amide group. Streptimidone (1) and 3 showed weak cytotoxic activity against three human cancer cell lines, respectively.-
dc.publisherSpringer-Nature Pub Group-
dc.titleIsolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening-
dc.title.alternativeIsolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number0-
dc.citation.endPage188-
dc.citation.startPage184-
dc.citation.volume73-
dc.contributor.affiliatedAuthorByeongsan Lee-
dc.contributor.affiliatedAuthorSangkeun Son-
dc.contributor.affiliatedAuthorJae Kyoung Lee-
dc.contributor.affiliatedAuthorMina Jang-
dc.contributor.affiliatedAuthorKyung Taek Heo-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorDong Jin Park-
dc.contributor.affiliatedAuthorChan Sun Park-
dc.contributor.affiliatedAuthorChang-Jin Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeName이병산-
dc.contributor.alternativeName손상근-
dc.contributor.alternativeName이재경-
dc.contributor.alternativeName장민아-
dc.contributor.alternativeName허경택-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName박동진-
dc.contributor.alternativeName박찬선-
dc.contributor.alternativeName김창진-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName황방연-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName홍영수-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 73, pp. 184-188-
dc.identifier.doi10.1038/s41429-019-0264-y-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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