Cytochrome C-decorated graphene field-effect transistor for highly sensitive hydrogen peroxide detection

Cited 13 time in scopus
Metadata Downloads
Cytochrome C-decorated graphene field-effect transistor for highly sensitive hydrogen peroxide detection
S H Lee; Kyung Ho Kim; Sung Eun Seo; Moonil Kim; Seon Joo Park; Oh Seok Kwon
Bibliographic Citation
Journal of Industrial and Engineering Chemistry, vol. 83, pp. 29-34
Publication Year
High-level in vivo reactive oxygen species (ROS) can damage many biomolecules via oxidative stress and play vital roles in the pathogenesis of several bodily disorders. Therefore, fast and sensitive monitoring strategies for trace ROS, such as hydrogen peroxide (H2O2), are of great significance. Herein, we present a highly sensitive field-effect transistor (FET) sensor based on single-layer graphene for trace hydrogen peroxide (H2O2) detection. Graphene and cytochrome c (Cyt c) were employed as the conductive substrate material and biomolecular receptor for H2O2 detection, respectively. High-efficiency charge transfer can be achieved by reliable electrical contact across the Cyt c/underlying graphene interface. The Cyt c/graphene FET platform exhibited hole-transport behavior with high conductivity and high sensitivity toward H2O2 with a detection limit of 100 fM and rapid response time (<1 s). Moreover, our sensor platform was able to specifically discriminate H2O2 from a series of interfering substances, such as dopamine, ascorbic acid, glucose, uric acid and glutamate. This result, therefore, demonstrates that the proposed Cyt c/single-layer graphene FET sensor could facilitate the high-efficiency charge transfer between the redox center of the Cyt c/graphene interface, indicating a promising application in future trace H2O2 or free radical biosensors.
Chemical sensorCytochrome cGraphene field-effect transistorHydrogen peroxide
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.