Chronic infiltration of T lymphocytes into the brain in a non-human primate model of Parkinson’s disease = 만성 파킨슨병 원숭이 모델에서 관찰되는 뇌조직내 T-cells

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Title
Chronic infiltration of T lymphocytes into the brain in a non-human primate model of Parkinson’s disease = 만성 파킨슨병 원숭이 모델에서 관찰되는 뇌조직내 T-cells
Author(s)
Jincheol Seo; Junghyung Park; Keonwoo Kim; Jinyoung Won; Hyeon-Gu Yeo; Yeung Bae Jin; Bon Sang KooKyung Seob LimKang Jin JeongPhilyong KangHwal Yong LeeWon Seok ChoiSeung Ho BaekChang Yeop JeonJung Joo HongJae Won HuhYoung-Hyun KimSang Je ParkSun-Uk Kim; D S Lee; Sang-Rae Lee; Youngjeon Lee
Bibliographic Citation
Neuroscience, vol. 431, pp. 73-85
Publication Year
2020
Abstract
Study of interactions between the nervous system and immunity offers insights into the pathogenesis of Parkinson's disease (PD) and potential therapeutic strategies for neurodegenerative diseases. Studies on rodents have revealed regulatory mechanisms of microglial activation and T lymphocyte recruitment in PD. However, the mechanisms underlying chronic T lymphocyte infiltration into the brain after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection into a non-human primate (NHP) model of PD remain unknown. This study aimed to investigate changes in serum RANTES (regulated on activation, normal T cell expression and secretion) and analyze the chronic infiltration of T lymphocytes into the brain and microglia activation in NHPs at 48?weeks post-MPTP administration. We found selective and local chronic infiltration of CD4+ and CD8+ T lymphocytes, loss of dopaminergic neurons, dopamine transporter expression, chronic normalization of RANTES in the peripheral blood, and altered microglial morphology at 48?weeks after MPTP injection. This study confirms the involvement of CD4+ and CD8+ T lymphocyte infiltration in MPTP-induced NHP models of PD. Additionally, we corroborated previous findings regarding the mechanisms of T lymphocyte-induced neurodegeneration. The findings of chronic infiltration of T lymphocytes in our NHP model of PD provide novel insights into PD pathogenesis and the development of preventive and therapeutic agents.
Keyword
MPTPParkinson’s diseaseRANTEST-celldopamine transporternon-human primate
ISSN
0306-4522
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.neuroscience.2020.01.043
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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