Cited 13 time in
- Title
- Chronic infiltration of T lymphocytes into the brain in a non-human primate model of Parkinson’s disease = 만성 파킨슨병 원숭이 모델에서 관찰되는 뇌조직내 T-cells
- Author(s)
- Jincheol Seo; Junghyung Park; Keonwoo Kim; Jinyoung Won; Hyeon-Gu Yeo; Yeung Bae Jin; Bon Sang Koo; Kyung Seob Lim; Kang Jin Jeong; Philyong Kang; Hwal Yong Lee; Won Seok Choi; Seung Ho Baek; Chang Yeop Jeon; Jung Joo Hong; Jae Won Huh; Young-Hyun Kim; Sang Je Park; Sun-Uk Kim; D S Lee; Sang-Rae Lee; Youngjeon Lee
- Bibliographic Citation
- Neuroscience, vol. 431, pp. 73-85
- Publication Year
- 2020
- Abstract
- Study of interactions between the nervous system and immunity offers insights into the pathogenesis of Parkinson's disease (PD) and potential therapeutic strategies for neurodegenerative diseases. Studies on rodents have revealed regulatory mechanisms of microglial activation and T lymphocyte recruitment in PD. However, the mechanisms underlying chronic T lymphocyte infiltration into the brain after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection into a non-human primate (NHP) model of PD remain unknown. This study aimed to investigate changes in serum RANTES (regulated on activation, normal T cell expression and secretion) and analyze the chronic infiltration of T lymphocytes into the brain and microglia activation in NHPs at 48weeks post-MPTP administration. We found selective and local chronic infiltration of CD4+ and CD8+ T lymphocytes, loss of dopaminergic neurons, dopamine transporter expression, chronic normalization of RANTES in the peripheral blood, and altered microglial morphology at 48weeks after MPTP injection. This study confirms the involvement of CD4+ and CD8+ T lymphocyte infiltration in MPTP-induced NHP models of PD. Additionally, we corroborated previous findings regarding the mechanisms of T lymphocyte-induced neurodegeneration. The findings of chronic infiltration of T lymphocytes in our NHP model of PD provide novel insights into PD pathogenesis and the development of preventive and therapeutic agents.
- Keyword
- non-human primateMPTPParkinson’s diseaseRANTEST-celldopamine transporter
- ISSN
- 0306-4522
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.neuroscience.2020.01.043
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
- Files in This Item:
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