Spiraea prunifolia var. simpliciflora attenuates oxidative stress and inflammatory responses in a murine model of lipopolysaccharide-iInduced acute lung injury and TNF-α-stimulated NCI-H292 cells

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dc.contributor.authorBa Wool Lee-
dc.contributor.authorJi Hye Ha-
dc.contributor.authorHan-Gyo Shin-
dc.contributor.authorSeong Hun Jeong-
dc.contributor.authorDa-Bin Jeon-
dc.contributor.authorJu-Hong Kim-
dc.contributor.authorJi Young Park-
dc.contributor.authorHyung Jun Kwon-
dc.contributor.authorKyungsook Jung-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorH Y Kim-
dc.contributor.authorS H Kim-
dc.contributor.authorHyun Jae Jang-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorIn Chul Lee-
dc.date.accessioned2020-04-24T16:30:20Z-
dc.date.available2020-04-24T16:30:20Z-
dc.date.issued2020-
dc.identifier.issn20763921-
dc.identifier.uri10.3390/antiox9030198ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19377-
dc.description.abstractSpiraea prunifolia var. simpliciflora (SP) is traditionally used as an herbal remedy to treat fever, malaria, and emesis. This study aimed to evaluate the anti-oxidative and anti-inflammatory properties of the methanol extract of SP leaves in tumor necrosis factor (TNF)-α-stimulated NCI-H292 cells and in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. SP decreased the number of inflammatory cells and the levels of TNF-α, interleukin (IL)-1β, and IL-6 in the bronchoalveolar lavage fluid, and inflammatory cell infiltration in the lung tissues of SP-treated mice. In addition, SP significantly suppressed the mRNA and protein levels of TNF-α, IL-1β, and IL-6 in TNF-α-stimulated NCI-H292 cells. SP significantly suppressed the phosphorylation of the mitogen-activated protein kinases (MAPKs) and p65-nuclear factor-kappa B (NF-κB) in LPS-induced ALI mice and TNF-α-stimulated NCI-H292 cells. SP treatment enhanced the nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2) with upregulated antioxidant enzymes and suppressed reactive oxygen species (ROS)-mediated oxidative stress in the lung tissues of LPS-induced ALI model and TNF-α-stimulated NCI-H292 cells. Collectively, SP effectively inhibited airway inflammation and ROS-mediated oxidative stress, which was closely related to its ability to induce activation of Nrf2 and inhibit the phosphorylation of MAPKs and NF-κB. These findings suggest that SP has therapeutic potential for the treatment of ALI.-
dc.publisherMDPI-
dc.titleSpiraea prunifolia var. simpliciflora attenuates oxidative stress and inflammatory responses in a murine model of lipopolysaccharide-iInduced acute lung injury and TNF-α-stimulated NCI-H292 cells-
dc.title.alternativeSpiraea prunifolia var. simpliciflora attenuates oxidative stress and inflammatory responses in a murine model of lipopolysaccharide-iInduced acute lung injury and TNF-α-stimulated NCI-H292 cells-
dc.typeArticle-
dc.citation.titleAntioxidants-
dc.citation.number0-
dc.citation.endPage198-
dc.citation.startPage198-
dc.citation.volume9-
dc.contributor.affiliatedAuthorBa Wool Lee-
dc.contributor.affiliatedAuthorJi Hye Ha-
dc.contributor.affiliatedAuthorHan-Gyo Shin-
dc.contributor.affiliatedAuthorSeong Hun Jeong-
dc.contributor.affiliatedAuthorDa-Bin Jeon-
dc.contributor.affiliatedAuthorJu-Hong Kim-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorHyung Jun Kwon-
dc.contributor.affiliatedAuthorKyungsook Jung-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.alternativeName이바울-
dc.contributor.alternativeName하지혜-
dc.contributor.alternativeName신한교-
dc.contributor.alternativeName정성훈-
dc.contributor.alternativeName전다빈-
dc.contributor.alternativeName김주홍-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName권형준-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName김현영-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName이인철-
dc.identifier.bibliographicCitationAntioxidants, vol. 9, pp. 198-198-
dc.identifier.doi10.3390/antiox9030198-
dc.subject.keywordAcute lung injury-
dc.subject.keywordAnti-oxidant activity-
dc.subject.keywordNuclear factor erythroid 2-related factor-
dc.subject.keywordNuclear factor-kappaB-
dc.subject.keywordSimpliciflora-
dc.subject.keywordSpiraea prunifolia var-
dc.subject.localAcute lung injury-
dc.subject.localAnti-oxidant activity-
dc.subject.localAntioxidant activity-
dc.subject.localNuclear factor erythroid 2-related factor-
dc.subject.localNuclear factor-kappaB-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localSimpliciflora-
dc.subject.localSpiraea prunifolia var-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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