Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species

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dc.contributor.authorSangkeun Son-
dc.contributor.authorMina Jang-
dc.contributor.authorByeongsan Lee-
dc.contributor.authorJung-Sook Lee-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2020-04-24T16:30:21Z-
dc.date.available2020-04-24T16:30:21Z-
dc.date.issued2020-
dc.identifier.issn0960894X-
dc.identifier.uri10.1016/j.bmcl.2020.127005ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19382-
dc.description.abstractTwo new macrolide metabolites of the hygrolidin family, catenulisporidins A and B (1 and 2), together with a known compound hygrolidin (3), were isolated from the culture broth of the rare actinobacterium Catenulispora sp. KCB13F192. Their structures were elucidated on the basis of HRESIMS spectrometric and NMR spectroscopic analyses. Catenulisporidins A and B are the first example of natural hygrolidin and bafilomycin derivatives featuring a modified macrolide ring, and catenulisporidin A possesses a tetrahydrofuran ring through an ether linkage between C-7 and C-10. In cell-based fluorescent imaging and immunoblot assays, the three compounds were shown to inhibit autophagic flux in HeLa cells.-
dc.publisherElsevier-
dc.titleCatenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species-
dc.title.alternativeCatenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number7-
dc.citation.endPage127005-
dc.citation.startPage127005-
dc.citation.volume30-
dc.contributor.affiliatedAuthorSangkeun Son-
dc.contributor.affiliatedAuthorMina Jang-
dc.contributor.affiliatedAuthorByeongsan Lee-
dc.contributor.affiliatedAuthorJung-Sook Lee-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName손상근-
dc.contributor.alternativeName장민아-
dc.contributor.alternativeName이병산-
dc.contributor.alternativeName이정숙-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 30, no. 7, pp. 127005-127005-
dc.identifier.doi10.1016/j.bmcl.2020.127005-
dc.subject.keywordActinomycetes-
dc.subject.keywordAutophagy-
dc.subject.keywordHygrolidins-
dc.subject.keywordSecondary metabolites-
dc.subject.localActinomycetes-
dc.subject.localAutophagy-
dc.subject.localHygrolidins-
dc.subject.localSecondary metabolites-
dc.subject.localSecondary metabolite-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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