Sicyos angulatus prevents high-fat diet-induced obesity and insulin resistance in mice

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Title
Sicyos angulatus prevents high-fat diet-induced obesity and insulin resistance in mice
Author(s)
Ji Hyun Choi; Jung-Ran NohYong-Hoon Kim; Jae-Hoon Kim; Eun Jung Kang; Dong Hee ChoiJung-Hyeon Choi; J P An; W K Oh; Chul Ho Lee
Bibliographic Citation
International Journal of Medical Sciences, vol. 17, no. 6, pp. 787-798
Publication Year
2020
Abstract
Obesity is a medical condition in which excess body fat has accumulated to a serious extent. It is a chronic disease that can lead to dyslipidemia, insulin resistance, and type 2 diabetes. In the present study, we investigated the anti-obesity effects of Sicyos angulatus (SA) extract on a high-fat diet (HFD)-induced C57BL/6J obese mice. The mice were divided into vehicle and three SA groups (25, 50, and 100 mg/kg body weight). The mice were fed a HFD with or without SA for 12 weeks. The oral administration of SA reduced body and adipose tissue weight in HFD-fed mice compared to those in the vehicle group (p<0.05). Adipocyte size and inflammation significantly decreased in the SA-administered groups in a dose-dependent manner. In particular, adipocytes larger than 5000 μm2 were remarkably reduced by around 50% in the SA-treated groups (p<0.05). In addition, SA contributes towards reducing insulin resistance (measured as the HOMA-IR index) and glucose intolerance in HFD-induced obese mice (p<0.05; Vehicle 21.5±3.1 vs. SA100 4.7±0.4). These beneficial effects of SA on obesity may be linked to the suppression of lipogenesis and stimulating energy metabolism in white adipose tissue and muscle. In white adipose tissue and muscle, the administration of SA activated AMPK pathway, leading to the inhibition of the development of pathophysiological conditions associated with obesity, including lipogenesis and inflammation. These findings suggest that SA may prevent obesity through inhibiting fat accumulation in HFD-induced obese mice. Therefore, SA is able to exert metabolic benefits in the prevention of obesity and insulin resistance.
Keyword
Sicyos angulatushigh-fat dietinsulin resistancelipogenesisobesity
ISSN
1449-1907
Publisher
Ivyspring Int Publ
DOI
http://dx.doi.org/10.7150/ijms.42247
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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