Metabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species = Lagerstroemia 종의 항당뇨 활성에 영향을 미치는 활성성분을 판별하기위한 대사체학 접근

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dc.contributor.authorMun-Ock Kim-
dc.contributor.authorSu Ui Lee-
dc.contributor.authorH J Yuk-
dc.contributor.authorHyun Jae Jang-
dc.contributor.authorJae Won Lee-
dc.contributor.authorEunbin Kwon-
dc.contributor.authorJin Hyub Paik-
dc.contributor.authorSangho Choi-
dc.contributor.authorA Nizar-
dc.contributor.authorT T Bach-
dc.contributor.authorK Sydara-
dc.contributor.authorH Jin-
dc.contributor.authorWoo So Yeun-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorHyung Won Ryu-
dc.date.accessioned2020-04-24T16:30:28Z-
dc.date.available2020-04-24T16:30:28Z-
dc.date.issued2020-
dc.identifier.issn1756-4646-
dc.identifier.uri10.1016/j.jff.2019.103684ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19408-
dc.description.abstractRational and efficient approaches to research and development are becoming more popular for increasing value enhancement in bioactive materials. In this study, metabolite profiles of 17 different Lagerstroemia species from different countries were performed using UPLC-QTof-MS combined with chemometric tools to identify potential metabolite predictors of antidiabetic activity. PLS-DA of the Lagerstroemia samples indicated two large, distinct clusters in the score plot. On the loading scatter plot, significant changes in metabolites of antidiabetic candidates were found between species, and two flavonol glycosides and corosolic acid were evaluated as key markers among the 25 analyzed metabolites. Based on the screening results, samples high in two triterpenic acids (corosolic acid and asiatic acid) showed a tendency to inhibit glucose uptake, which could have contributed to the correlation of active and inactive extracts. Therefore, these comprehensive results support our biochemometric models and contribute to the rational and efficient studies of pharmacologically active metabolites.-
dc.publisherElsevier-
dc.titleMetabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species = Lagerstroemia 종의 항당뇨 활성에 영향을 미치는 활성성분을 판별하기위한 대사체학 접근-
dc.title.alternativeMetabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species-
dc.typeArticle-
dc.citation.titleJournal of Functional Foods-
dc.citation.number0-
dc.citation.endPage103684-
dc.citation.startPage103684-
dc.citation.volume64-
dc.contributor.affiliatedAuthorMun-Ock Kim-
dc.contributor.affiliatedAuthorSu Ui Lee-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorJae Won Lee-
dc.contributor.affiliatedAuthorEunbin Kwon-
dc.contributor.affiliatedAuthorJin Hyub Paik-
dc.contributor.affiliatedAuthorSangho Choi-
dc.contributor.affiliatedAuthorWoo So Yeun-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.alternativeName김문옥-
dc.contributor.alternativeName이수의-
dc.contributor.alternativeName육흥주-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName이재원-
dc.contributor.alternativeName권은빈-
dc.contributor.alternativeName백진협-
dc.contributor.alternativeName최상호-
dc.contributor.alternativeNameNizar-
dc.contributor.alternativeNameBach-
dc.contributor.alternativeNameSydara-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName우소연-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName류형원-
dc.identifier.bibliographicCitationJournal of Functional Foods, vol. 64, pp. 103684-103684-
dc.identifier.doi10.1016/j.jff.2019.103684-
dc.subject.keywordAntidiabetic-
dc.subject.keywordCorosolic acid-
dc.subject.keywordFlavonol glycosides-
dc.subject.keywordLagerstroemia-
dc.subject.keywordMetabolomics-
dc.subject.localAntidiabetic-
dc.subject.localAnti-diabetic-
dc.subject.localantidiabetic-
dc.subject.localCorosolic acid-
dc.subject.localcorosolic acid-
dc.subject.localFlavonol glycosides-
dc.subject.localflavonol glycoside-
dc.subject.localLagerstroemia-
dc.subject.localMetabolomics-
dc.subject.localmetabolomics-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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