Salient features of monomeric alpha-synuclein revealed by NMR spectroscopy

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Title
Salient features of monomeric alpha-synuclein revealed by NMR spectroscopy
Author(s)
Do-Hyoung Kim; J Lee; K H Mok; J H Lee; Kyou Hoon Han
Bibliographic Citation
Biomolecules, vol. 10, no. 3, pp. 428-428
Publication Year
2020
Abstract
Elucidating the structural details of proteins is highly valuable and important for the proper understanding of protein function. In the case of intrinsically disordered proteins (IDPs), however, obtaining the structural details is quite challenging, as the traditional structural biology tools have only limited use. Nuclear magnetic resonance (NMR) is a unique experimental tool that provides ensemble conformations of IDPs at atomic resolution, and when studying IDPs, a slightly different experimental strategy needs to be employed than the one used for globular proteins. We address this point by reviewing many NMR investigations carried out on the α-synuclein protein, the aggregation of which is strongly correlated with Parkinson's disease.
Keyword
pre-structured motifs (PreSMos)secondary structure propensityNMRalpha-synucleinintrinsically disordered protein
ISSN
2218-273X
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/biom10030428
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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