Excess accumulation of lipid impairs insulin sensitivity in skeletal muscle

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Title
Excess accumulation of lipid impairs insulin sensitivity in skeletal muscle
Author(s)
Sung Sup ParkYoung Kyo Seo
Bibliographic Citation
International Journal of Molecular Sciences, vol. 21, no. 6, pp. 1949-1949
Publication Year
2020
Abstract
Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid droplets leads to intramuscular accumulation of lipid intermediates. The resulting downregulation of the insulin signaling cascade prevents the translocation of glucose transporter to the plasma membrane and glucose uptake into skeletal muscle, leading to metabolic disorders such as type 2 diabetes. The mechanisms underlining metabolic dysfunction in skeletal muscle include accumulation of intracellular lipid derivatives from elevated plasma FFAs. This paper provides a review of the molecular mechanisms underlying insulin-related signaling pathways after excess accumulation of lipids.
Keyword
free fatty acidinsulin sensitivitymetabolic dysfunctionskeletal muscle
ISSN
1661-6596
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms21061949
Type
Article
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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