Quantitative magnetic susceptibility assessed by 7T magnetic resonance imaging in Alzheimer's disease caused by streptozotocin administration

Cited 8 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorS Kim-
dc.contributor.authorYoungjeon Lee-
dc.contributor.authorChang Yeop Jeon-
dc.contributor.authorK Kim-
dc.contributor.authorY Jeon-
dc.contributor.authorYeung Bae Jin-
dc.contributor.authorS Oh-
dc.contributor.authorC Lee-
dc.date.accessioned2020-04-24T16:30:37Z-
dc.date.available2020-04-24T16:30:37Z-
dc.date.issued2020-
dc.identifier.issn1223-4292-
dc.identifier.uri10.21037/qims.2020.02.08ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19448-
dc.description.abstractStreptozotocin treatment has emerged as an alternative model of sporadic Alzheimer's disease (SAD). Streptozotocin-induced alterations in iron and calcium levels reflect magnetic susceptibility changes, while susceptibility distribution in the cerebral regions has not been reported yet. This study aimed to investigate susceptibility distribution in the limbic system after streptozotocin administration to cynomolgus monkeys for exploring informative SAD biomarkers. Quantitative susceptibility mapping (QSM) using 7T magnetic resonance imaging (MRI) was utilized to quantitatively compare the susceptibility distributions in monkeys with sporadic Alzheimer disease and age-matched healthy controls. Compared to healthy controls, overall susceptibility values differed in the SAD models. Notable substantial susceptibility changes were observed in the hypothalamus with a 4.38-time decrease (AD: -47.45±12.19 ppb, healthy controls: 14.02±9.51 ppb) and in the posterior parts of the corpus callosum with a 2.83-times increase (AD: 31.49±15.90 ppb; healthy controls: 11.13±4.02 ppb). These susceptibility alterations may reflect neuronal death, and could serve as key biomarkers in the SAD. These results may be useful for specifying AD pathologies such as cognitive and non-cognitive symptoms.-
dc.publisherAME Publ Co-
dc.titleQuantitative magnetic susceptibility assessed by 7T magnetic resonance imaging in Alzheimer's disease caused by streptozotocin administration-
dc.title.alternativeQuantitative magnetic susceptibility assessed by 7T magnetic resonance imaging in Alzheimer's disease caused by streptozotocin administration-
dc.typeArticle-
dc.citation.titleQuantitative Imaging in Medicine and Surgery-
dc.citation.number3-
dc.citation.endPage797-
dc.citation.startPage789-
dc.citation.volume10-
dc.contributor.affiliatedAuthorYoungjeon Lee-
dc.contributor.affiliatedAuthorChang Yeop Jeon-
dc.contributor.affiliatedAuthorYeung Bae Jin-
dc.contributor.alternativeName김상우-
dc.contributor.alternativeName이영전-
dc.contributor.alternativeName전창엽-
dc.contributor.alternativeName김근일-
dc.contributor.alternativeName전영재-
dc.contributor.alternativeName진영배-
dc.contributor.alternativeName오석훈-
dc.contributor.alternativeName이철현-
dc.identifier.bibliographicCitationQuantitative Imaging in Medicine and Surgery, vol. 10, no. 3, pp. 789-797-
dc.identifier.doi10.21037/qims.2020.02.08-
dc.subject.keywordAlzheimer’s disease (AD)-
dc.subject.keywordmagnetic resonance imaging (MRI)-
dc.subject.keywordquantitative susceptibility mapping (QSM)-
dc.subject.keywordstreptozotocin-
dc.subject.keywordultra-high field-
dc.subject.localalzheimer's disease-
dc.subject.localAlzheimer’s disease (AD)-
dc.subject.localAlzheimer’s disease-
dc.subject.localAlzheimer's Disease-
dc.subject.localAlzheimer disease-
dc.subject.localAlzheimer's disease (AD)-
dc.subject.localAlzheimer′s disease-
dc.subject.localAlzheimer's disease-
dc.subject.localmagnetic resonance imaging (MRI)-
dc.subject.localMagnetic Resonance Imaging-
dc.subject.localmagnetic resonance imaging-
dc.subject.localMagnetic resonance imaging-
dc.subject.localMRI-
dc.subject.localMagnetic resonance imaging (MRI)-
dc.subject.localquantitative susceptibility mapping (QSM)-
dc.subject.localstreptozotocin-
dc.subject.localstreptozotocin (STZ)-
dc.subject.localStreptozotocin-
dc.subject.localUltra-high field-
dc.subject.localultra-high field-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.