Personalized Genomic Medicine Research Center (유전체맞춤의료전문연구단)584

연구분야

  • Genome-wide 유전자 발현 제어기술을 이용한 맞춤의료 기술 개발
    • Genome-wide shRNA 기반 암 치료표적 유전자 발굴 및 치료기술 개발
    • Genome-wide CRISPR 시스템 기반 암 치료표적 유전자 발굴 및 치료기술 개발
  • 후성유전체 분석 기술을 이용한 세포분화 연구 및 세포분화제어기술 개발
    • 단일세포 DNA 메틸화, 크로마틴 구조 분석 및 다양한 히스톤 변형 분석 기술 확립
    • 다양한 후성유전체 정보 분석 파이프라인 구축 및 분석 소프트웨어 개발
    • 후성유전체 분석 기반 세포분화 제어기술 개발
    • 줄기세포의 분화 과정에서 DNA methylome, Histonemodification, transcriptome 변화를 비교 분석하여 후성유전인자 상호간의 네트워크연구
    • 줄기세포 분화의 모니터링을 위한 바이오마커 개발
    • NGS를 이용한 표적치료제 내성 획득 암세포의 Transcriptome, DNA methylome, Histone modification 통합 분석
    • 항암제 내성의 지표가 되는 epimutation 동정
더보기

Showing results 1 to 20 of 346

No. Year Title Type
1 2024

2024Article

Loliolide in Sargassum horneri alleviates ultrafine urban particulate matter (PM 0.1)-induced inflammation in human RPE cellsInternational Journal of Molecular Sciences, vol. 25, no. 1, pp. 162-162E J Lee; S Lee; Hyun-Jae JangWonbeak Yoo
Article
2 2024

2024Article

Comparative genomics reveals the dynamic evolutionary history of cement protein genes of barnacles from intertidal to deep-sea hydrothermal ventsMolecular Ecology Resources, vol. 24, no. 2, pp. e13895-e13895Won Kyung Lee; B K K Chan; Jae-Yoon Kim; S J Ju; Se-Joo Kim
Article
3 2024

2024Article

CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathwaysExperimental and Molecular Medicine, vol. 56, no. 1, pp. 235-249Joo-Young Im; S J Kim; Jong Lyul Park; Tae Hee Han; Woo-Il Kim; Inhyub Kim; Bomin Ko; So-Young Chun; Mi-Jung KangBo Kyung Kim, et al.
Article
4 2024

2024Article

Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analysesNature Communications, vol. 15, pp. 1163-1163S E Lee; S Park; S Yi; N R Choi; M A Lim; J W Chang; H R Won; J R Kim; H M Ko; E J Chung, et al.
Article
5 2024

2024Article

Comprehensive analysis on clinical significance and therapeutic targets of LDL receptor related protein 11 (LRP11) in liver hepatocellular carcinomaFrontiers in Pharmacology, vol. 15, pp. 1338929-1338929Wonbeak YooAe-Kyeong Kim; Hae Un Kook; Kyung Hee Noh
Article
6 2024

2024Article

PEG-capped ceria-zirconia nanoparticles improved renal fibrosis in cellular and animal models of fabry diseaseACS Applied Nano Materials, vol. 7, no. 3, pp. 2913-2928E K Kim; S E Hong; Y Li; S L Yu; Y S Choi; J Kang; C G Park; H Y Lee; S K Lee; Dong Chul Lee, et al.
Article
7 2024

2024Article

A 23-gene prognostic index predicts progression and bacillus Calmette-Guerin response in non-muscle-invasive bladder cancerEuropean Urology, vol. 85, no. 4, pp. 400-402Seon-Kyu Kim; Y J Byun; Seong-Hwan Park; X M Piao; C M Zheng; S Moon; K Kim; S J Song; H W Kang; W T Kim, et al.
Article
8 2023

2023Article

TNF-α secreted from macrophages increases the expression of prometastatic integrin αV in gastric cancerInternational Journal of Molecular Sciences, vol. 24, no. 1, pp. 376-376Mi Aie Hwang; Misun Won; Joo-Young ImMi-Jung Kang; D H Kweon; Bo Kyung Kim
Article
9 2023

2023Article

Regulating POLR3G by microRNA-26a-5p as a promising therapeutic target of lung cancer stemness and chemosensitivityNon-coding RNA Research, vol. 8, no. 3, pp. 273-281C R Park; M Lee; S Y Lee; D Kang; S J Park; Dong Chul Lee; Han Koo; Y G Park; S L Yu; I B Jeong, et al.
Article
10 2023

2023Article

Exosomal miR-205-5p improves endometrial receptivity by upregulating E-cadherin expression through ZEB1 inhibitionInternational Journal of Molecular Sciences, vol. 24, no. 20, pp. 15149-15149S L Yu; D U Jeong; E J Noh; H J Jeon; Dong Chul LeeMinho Kang; T H Kim; S K Lee; A R Han; J Kang, et al.
Article
11 2023

2023Article

DNA methylome profiling of blood to identify individuals in a pair of monozygotic twinsGenes & Genomics, vol. 45, no. 10, pp. 1273-1279Jae-Yoon Kim; H Y Lee; So Yeon Lee; Seon-Young KimJong Lyul Park; S D Lee
Article
12 2023

2023Article

Diagnosis of Crohn's disease and ulcerative colitis using the microbiomeBMC Microbiology, vol. 23, pp. 336-336Da-Yeon Kang; Jong Lyul Park; MK Yeo; S B Kang; J M Kim; J S Kim; Seon-Young Kim
Article
13 2023

2023Article

Hypoxia stabilizes SETDB1 to maintain genome stabilityNucleic Acids Research, vol. 51, no. 20, pp. 11178-11196Sungryul Park; Jin Hwa ChoJong-Hwan Kim; Mijin Park; Seulki Park; Seon-Young KimSeon-Kyu Kim; K Kim; Sung Goo ParkByoung Chul Park, et al.
Article
14 2023

2023Article

Design, synthesis and biological evaluation of novel MDH inhibitors targeting tumor microenvironmentPharmaceuticals, vol. 16, no. 5, pp. 683-683S Godesi; Jeong-Ran Han; Jang Keun Kim; D I Kwak; J Lee; H Nada; M Kim; Hyun A Yang; Joo-Young ImHyun Seung Ban, et al.
Article
15 2023

2023Article

SAMD13 serves as a useful prognostic biomarker for hepatocellular carcinomaEuropean Journal of Medical Research, vol. 28, pp. 514-514Wonbeak Yoo; S Kim; Kyung Hee Noh
Article
16 2023

2023Article

DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancerExperimental and Molecular Medicine, vol. 55, no. 5, pp. 879-885Joo-Young ImMi-Jung KangBo Kyung Kim; Mi Sun Won
Article
17 2023

2023Article

Identification of NIFTP-specific mRNA markers for reliable molecular diagnosis of thyroid tumorsEndocrine Pathology, vol. 34, no. 3, pp. 311-322So-Yeon Lee; Jong Lyul Park; K Kim; J S Bae; Jae-Yoon KimSeon-Young Kim; C K Jung
Article
18 2023

2023Article

Deciphering the DNA methylation landscape of colorectal cancer in a Korean cohortBMB Reports, vol. 56, no. 10, pp. 569-574S B Lim; Soobok Joe; H J Kim; J L Lee; I J Park; Y S Yoon; C W Kim; Jong-Hwan KimSangok Kim; J U Lee, et al.
Article
19 2023

2023Article

Epigenetic insights into colorectal cancer: comprehensive genome-wide DNA methylation profiling of 294 patients in KoreaBMB Reports, vol. 56, no. 10, pp. 563-568Soobok Joe; J Kim; J Y Lee; Jongbum JeonIksu Byeon; S W Han; S B Ryoo; K J Park; S H Song; S Cho, et al.
Article
20 2023

2023Article

Generation and analysis of whole-genome sequencing data in human mammary epithelial cellsGenomics & Informatics, vol. 21, no. 1, pp. e11-e11Jong Lyul ParkJae-Yoon KimSeon-Young Kim; Y S Lee
Article
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