Personalized Genomic Medicine Research Center (유전체맞춤의료전문연구단)557

연구분야

  • Genome-wide 유전자 발현 제어기술을 이용한 맞춤의료 기술 개발
    • Genome-wide shRNA 기반 암 치료표적 유전자 발굴 및 치료기술 개발
    • Genome-wide CRISPR 시스템 기반 암 치료표적 유전자 발굴 및 치료기술 개발
  • 후성유전체 분석 기술을 이용한 세포분화 연구 및 세포분화제어기술 개발
    • 단일세포 DNA 메틸화, 크로마틴 구조 분석 및 다양한 히스톤 변형 분석 기술 확립
    • 다양한 후성유전체 정보 분석 파이프라인 구축 및 분석 소프트웨어 개발
    • 후성유전체 분석 기반 세포분화 제어기술 개발
    • 줄기세포의 분화 과정에서 DNA methylome, Histonemodification, transcriptome 변화를 비교 분석하여 후성유전인자 상호간의 네트워크연구
    • 줄기세포 분화의 모니터링을 위한 바이오마커 개발
    • NGS를 이용한 표적치료제 내성 획득 암세포의 Transcriptome, DNA methylome, Histone modification 통합 분석
    • 항암제 내성의 지표가 되는 epimutation 동정
더보기

Showing results 1 to 20 of 442

No. Year Title Type
1 2021

2021Article

PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironmentFEBS Journal, vol. 288, no. 9, pp. 2888-2910A Y Yang; E B Choi; M S Park; Seon-Kyu Kim; M S Park; M Y Kim
Article
2 2021

2021Article

DGG-100629 inhibits lung cancer growth by suppressing the NFATc1/DDIAS/STAT3 pathwayExperimental and Molecular Medicine, vol. 53, no. 4, pp. 643-653Joo-Young ImBo Kyung Kim; S H Yoon; B C Cho; Y M Baek; Mi-Jung Kang; N Kim; Y D Gong; Mi Sun Won
Article
3 2021

2021Article

Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cellsBiomedicine & Pharmacotherapy, vol. 133, pp. 111082-111082Min Kyung Park; Z Ji; Keeok Haam; Tae Hee Han; Seona Lim; Mi-Jung Kang; S S Lim; Hyun Seung Ban
Article
4 2021

2021Article

VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signalingBiochimica et Biophysica Acta-Molecular Cell Research, vol. 1868, pp. 118892-118892Joo-Young Im; Da Mi Kim; Hyunkyung Park; Mi-Jung Kang; Da Yoon Kijm; K Y Chang; Bo Kyung KimMi Sun Won
Article
5 2021

2021Article

STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse modelOncology Reports, vol. 45, no. 4, pp. 42-42Dong Hyuck Bae; Hee Jin Kim; Byoung Ha Yoon; Jong Lyul ParkMirang KimSeon-Kyu KimSeon-Young Kim; S I Lee; K S Song; Yong Sung Kim
Article
6 2021

2021Article

Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancerBreast Cancer Research and Treatment, vol. 188, no. 1, pp. 165-178S G Ahn; Seon-Kyu Kim; J H Shepherd; Y J Cha; S J Bae; C Kim; J Jeong; C M Perou
Article
7 2021

2021Article

Comparison between MGI and Illumina sequencing platforms for whole genome sequencingGenes & Genomics, vol. 43, no. 7, pp. 713-724Sol A Jeon; Jong Lyul Park; Seung Jin Park; Jeong Hwan Kim; S H Goh; J Y Han; Seon-Young Kim
Article
8 2021

2021Article

Long-term depletion of Cereblon induces mitochondrial dysfunction in cancer cellsBMB Reports, vol. 54, no. 6, pp. 305-310Seulki Park; K Kim; Keeok Haam; Hyun Seung BanJung Ae KimByoung Chul ParkSung Goo Park; Sunhong Kim; Jeong Hoon Kim
Article
9 2021

2021Article

Transcriptomic analysis and competing endogenous RNA network in the human endometrium between proliferative and mid-secretory phasesExperimental and Therapeutic Medicine, vol. 21, no. 6, pp. 660-660S L Yu; T H Kim; Y H Han; Y Kang; D U Jeong; Dong Chul Lee; J Kang; S R Park
Article
10 2021

2021Article

8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generationPhytotherapy Research, vol. 35, pp. 1508-1520Yujin Lee; Jiyeon Choi; Yae Jin Yoon; Yugyeong Sim; Hyung Won RyuSei-Ryang OhDoo-Young Kim; Jihyun Hwang; Seung-Wook ChiDong Cho Han, et al.
Article
11 2021

2021Article

Analysis of genomic pathogenesis according to the revised Bethesda guidelines and additional criteriaJournal of Cancer Research and Clinical Oncology, vol. 147, no. 1, pp. 117-128J C Kim; Jong-Hwan Kim; Y J Ha; Chan Wook Kim; K H Tak; Y S Yoon; Y H Kwon; S A Roh; D H Cho; Seon-Kyu Kim, et al.
Article
12 2021

2021Article

Nc886, a novel suppressor of the type I interferon response upon pathogen intrusionInternational Journal of Molecular Sciences, vol. 22, no. 4, pp. 2003-2003Y S Lee; X Bao; H H Lee; J J Jang; E Saruuldalai; G Park; W R Im; Jong Lyul ParkSeon-Young Kim; S Shin, et al.
Article
13 2021

2021Article

Simultaneous pro?ling of Arabidopsis thaliana and Vibrio vulni?cus MO6-24/O transcriptomes by dual RNA-seq analysisComputational and Structural Biotechnology Journal, vol. 19, pp. 2084-2096Y S Park; J S Park; Soohyun Lee; Sung-Hee Jung; Seon-Kyu KimChoong-Min Ryu
Article
14 2021

2021Article

MicroRNA profile for diagnostic and prognostic biomarkers in thyroid cancerCancers, vol. 13, no. 4, pp. 632-632Jong Lyul ParkSeon-Kyu Kim; S Jeon; C K Jung; Yong Sung Kim
Article
15 2021

2021Article

A molecular signature determines the prognostic and therapeutic subtype of non-muscle-invasive bladder cancer responsive to intravesical Bacillus Calmette-Guerin therapyInternational Journal of Molecular Sciences, vol. 22, no. 3, pp. 1450-1450Seon-Kyu Kim; Seonghwan Park; Y U Kim; Y J Byun; X M Piao; P Jeong; K Kim; H Y Lee; S P Seo; H W Kang, et al.
Article
16 2021

2021Article

Targeting HSF1 as a therapeutic strategy for multiple mechanisms of EGFR inhibitor resistance in EGFR mutant non-small-cell lung cancer = 활성 EGFR 발현 비소세포 폐암의 EGFR 표적항암제에 대한 다중 내성 치료표적으로의 HSF1Cancers, vol. 13, no. 12, pp. 2987-2987Sangah Lee; JiYae Jung; Yu-Jin LeeSeon-Kyu KimJung Ae KimBo Kyung KimKyung Chan ParkByoung-Mog KwonDong Cho Han
Article
17 2020

2020Article

EZH2 as a potential target for NAFLD therapyInternational Journal of Molecular Sciences, vol. 21, no. 22, pp. 8617-8617Hyunjung Lim; Mi Rang Kim
Article
18 2020

2020Article

Transcriptional profiling of advanced urothelial cancer predicts prognosis and response to immunotherapyInternational Journal of Molecular Sciences, vol. 21, no. 5, pp. 1850-1850Seung Woo Baek; In Hwan Jang; Seon-Kyu Kim; J K Nam; S H Leem; In-Sun Chu
Article
19 2020

2020Article

Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells = 기존 약물인 Ethacrynic acid의 항암 효과 관련 표적 발굴 및 검증Biochemical Pharmacology, vol. 175, pp. 113920-113920Yu Jin Lee; Harim Song; Yae Jin Yoon; Seung Jin Park; Seon-Young KimDong Cho HanByoung-Mog Kwon
Article
20 2020

2020Article

A regulatory noncoding RNA, nc886, suppresses esophageal cancer by inhibiting the AKT pathway and cell cycle progressionCells, vol. 9, pp. 801-801W R Lim; H S Lee; Y S Lee; J S Lee; H J Jang; Seon-Young KimJong Lyul Park; Y Lee; M S Kim; J M Lee, et al.
Article
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